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Leveraging Existing Cohorts to Study Health Effects of Air Pollution on Cardiometabolic Disorders: India Global Environmental and Occupational Health Hub

机译：利用现有研究人群研究空气污染对心脏代谢疾病的健康影响：印度全球环境与职业健康中心

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Air pollution is a growing public health concern in developing countries and poses a huge epidemiological burden. Despite the growing awareness of ill effects of air pollution, the evidence linking air pollution and health effects is sparse. This requires environmental exposure scientist and public health researchers to work more cohesively to generate evidence on health impacts of air pollution in developing countries for policy advocacy. In the Global Environmental and Occupational Health (GEOHealth) Program, we aim to build exposure assessment model to estimate ambient air pollution exposure at a very fine resolution which can be linked with health outcomes leveraging well-phenotyped cohorts which have information on geolocation of households of study participants. We aim to address how air pollution interacts with meteorological and weather parameters and other aspects of the urban environment, occupational classification, and socioeconomic status, to affect cardiometabolic risk factors and disease outcomes. This will help us generate evidence for cardiovascular health impacts of ambient air pollution in India needed for necessary policy advocacy. The other exploratory aims are to explore mediatory role of the epigenetic mechanisms (DNA methylation) and vitamin D exposure in determining the association between air pollution exposure and cardiovascular health outcomes. Other components of the GEOHealth program include building capacity and strengthening the skills of public health researchers in India through variety of training programs and international collaborations. This will help generate research capacity to address environmental and occupational health research questions in India. The expertise that we bring together in GEOHealth hub are public health, clinical epidemiology, environmental exposure science, statistical modeling, and policy advocacy.
机译：空气污染是发展中国家日益关注的公共卫生问题，并构成了巨大的流行病负担。尽管人们越来越意识到空气污染的不良影响，但将空气污染与健康影响联系起来的证据却很少。这就要求环境暴露科学家和公共卫生研究人员更加紧密地合作，以得出有关空气污染对发展中国家健康影响的证据，以进行政策倡导。在全球环境与职业健康（GEOHealth）计划中，我们旨在建立暴露评估模型，以非常精细的分辨率估算环境空气污染暴露，这可以与利用表型明确的队列的健康结果相关联，这些队列具有关于家庭住所地理位置的信息研究参与者。我们旨在解决空气污染如何与气象和天气参数以及城市环境，职业分类和社会经济状况的其他方面相互作用的问题，从而影响心脏代谢风险因素和疾病结果。这将有助于我们获得必要的政策倡导所需的印度环境空气污染对心血管健康的影响的证据。另一个探索性目标是探索表观遗传机制（DNA甲基化）和维生素D暴露在确定空气污染暴露与心血管健康结果之间的关联中的中介作用。 GEOHealth计划的其他组成部分包括通过各种培训计划和国际合作来增强印度公共卫生研究人员的能力和技能。这将有助于提高研究能力，以解决印度的环境和职业健康研究问题。我们在GEOHealth中心汇集的专业知识包括公共卫生，临床流行病学，环境暴露科学，统计模型和政策倡导。

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