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In Vitro Studies of Fermented Korean Chung-Yang Hot Pepper Phenolics as Inhibitors of Key Enzymes Relevant to Hypertension and Diabetes

机译:发酵朝鲜重阳辣椒酚类化合物作为与高血压和糖尿病相关的关键酶抑制剂的体外研究

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摘要

This study was investigated to evaluate the antioxidant activity, the angiotensin I-converting enzyme (ACE) inhibition effect, and the α-amylase and α-glucosidase inhibition activities of hot pepper water extracts both before and after their fermentation. The fermented pepper water extract (FP) showed significantly higher total phenol content, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical inhibition effect, metal chelating activity and ACE inhibition activity compared to the non-fermented raw pepper water extract (RP) ( < 0.05). Meanwhile, the FP showed lower α-amylase and higher α-glucosidase inhibitory activities, but the RP showed similar levels of α-amylase and α-glucosidase inhibitory activities. Taken together, these results suggested that fermented pepper extract using water should be expected to have potentially inhibitory effects against both hyperglycemia and hypertension.
机译:这项研究旨在评估辣椒水提取物发酵前后的抗氧化活性,血管紧张素I转化酶(ACE)抑制作用以及α-淀粉酶和α-葡萄糖苷酶抑制活性。与未发酵的生胡椒水提取物(RP)相比,发酵的胡椒水提取物(FP)表现出显着更高的总酚含量,1,1-二苯基-2-吡啶并肼基(DPPH)自由基抑制作用,金属螯合活性和ACE抑制活性。 )(<0.05)。同时,FP显示较低的α-淀粉酶和较高的α-葡萄糖苷酶抑制活性,但是RP显示相似水平的α-淀粉酶和α-葡萄糖苷酶抑制活性。综上所述,这些结果表明用水发酵的胡椒提取物应有望对高血糖症和高血压都有潜在的抑制作用。

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