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首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Molecular Epidemiology of Neisseria gonorrhoeae in Amsterdam The Netherlands Shows Distinct Heterosexual and Homosexual Networks
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Molecular Epidemiology of Neisseria gonorrhoeae in Amsterdam The Netherlands Shows Distinct Heterosexual and Homosexual Networks

机译：荷兰阿姆斯特丹淋病奈瑟菌的分子流行病学显示异性恋和同性恋网络

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Molecular typing, added to epidemiological data, can better identify transmission patterns of gonorrhea in Western countries, where the incidence has recently been rising. From September 2002 to September 2003, patients with a laboratory-confirmed diagnosis of gonorrhea at the Clinic for Sexually Transmitted Infections in Amsterdam, The Netherlands, were subjected to a questionnaire pertaining to sexual risk behavior and sexual partners in the 6 months prior to the diagnosis. The Neisseria gonorrhoeae isolates were all genotyped using PCR-restriction fragment length polymorphism of the porin and opacity genes. All patients with a completed questionnaire and genotyped isolates were included in the study. We obtained 885 N. gonorrhoeae isolates from 696 patients that revealed 88 clusters and 46 unique genotypes. Patients infected at multiple anatomical sites with one or more strains and patients infected several times during the study period were shown to pursue high-risk sexual behavior and were considered core groups. There were 11 clusters of ≥20 patients; in seven clusters, 81% to 100% of patients were men who have sex with men (MSM), three clusters contained 87 to 100% heterosexual men and women, and one cluster was formed by equal proportions of MSM and heterosexual male and female patients. However, the various clusters differed in characteristics such as types of coinfections, numbers of sexual partners, Internet use to seek sexual partners, and locations of sexual encounters. Molecular epidemiology of gonococcal isolates in Amsterdam revealed core groups and clusters of MSM and heterosexual patients that probably indicate distinct transmission networks.
机译：在流行病学数据中添加分子分型可以更好地识别淋病的传播方式，在西方国家，淋病的发病率最近在不断上升。从2002年9月至2003年9月，在荷兰阿姆斯特丹的性传播感染诊所经实验室确诊为淋病的患者，在诊断前的6个月内接受了有关性危险行为和性伴侣的问卷调查。使用孔蛋白和不透明基因的PCR-限制性片段长度多态性对淋病奈瑟氏球菌进行基因分型。所有具有完整问卷和基因型分离株的患者均纳入研究。我们从696名患者中获得了885株淋病奈瑟菌分离株，这些菌株揭示了88个簇和46个独特的基因型。研究期间，在多个解剖部位感染了一种或多种毒株的患者以及多次感染的患者表现出追求高风险的性行为，被视为核心人群。有11例≥20的患者。在七个类群中，有81％至100％的患者是与男性发生性关系的男性，三个类群包含87％至100％的异性恋男性和女性，其中一个类群是由等比例的MSM和异性恋男性和女性患者组成的。但是，各个群体的特征各不相同，例如，合并感染的类型，性伴侣的数量，使用互联网寻求性伴侣以及性接触的地点。在阿姆斯特丹，淋球菌分离株的分子流行病学揭示了MSM和异性恋患者的核心群体和集群，这可能表明存在不同的传播网络。

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