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首页> 外文期刊>The Journal of Infectious Diseases >Distinct Neisseria gonorrhoeae transmission networks among men who have sex with men in Amsterdam, The Netherlands.
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Distinct Neisseria gonorrhoeae transmission networks among men who have sex with men in Amsterdam, The Netherlands.

机译：荷兰阿姆斯特丹与男子发生性关系的男子中存在独特的淋病奈瑟氏球菌传播网络。

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Molecular typing was used to elucidate Neisseria gonorrhoeae transmission networks among men who have sex with men (MSM) in Amsterdam, the Netherlands. We determined whether clusters of patients infected with specific N. gonorrhoeae genotypes were related to various epidemiological characteristics.MSM (age ≥18 years) visiting the sexually transmitted infections (STI) clinic between July 2008 and August 2009 were eligible. After STI screening, participants completed a behavioral questionnaire concerning the previous 6 months. N. gonorrhoeae cultures were genotyped using multiple-locus variable-number tandem repeat analysis typing.We obtained 278 N. gonorrhoeae-positive isolates from 240 MSM. Five large clusters (≥10 isolates), a unique sixth cluster (n = 9), and 8 smaller clusters (5-9 isolates) were identified. Prevalence of human immunodeficiency virus differed between clusters I and VI (P = .003), ranging from 27.8% to 100%. Receptive unprotected anal intercourse was frequently reported by MSM (51.8%) but did not differ significantly among clusters. Significant differences were identified concerning the participant's history of syphilis (P = .030), having met partners at a popular sex venue in Amsterdam (P = .048), and meeting partners outside Amsterdam (P = .036).Distinct N. gonorrhoeae transmission networks were present in a mixed high-risk MSM population; concordance between clusters and epidemiological characteristics was present but not marked.
机译：在荷兰阿姆斯特丹，使用分子分型法阐明了淋病奈瑟氏球菌的传播网络。我们确定了感染特定淋病奈瑟氏球菌基因型的患者群是否与各种流行病学特征相关.2008年7月至2009年8月间访问性传播感染（STI）诊所的MSM（年龄≥18岁）是合格的。经过性传播感染筛查后，参与者完成了有关前6个月的行为问卷。使用多位点可变数串联重复分析分型对淋病奈瑟菌培养物进行基因分型。我们从240个MSM中获得了278个淋病奈瑟菌阳性菌株。确定了五个大型簇（≥10个分离株），唯一的第六个簇（n = 9）和8个较小的簇（5-9个分离株）。人类免疫缺陷病毒的感染率在群集I和群集VI之间有所不同（P = 0.003），范围从27.8％至100％。 MSM经常报告接受无保护的肛门性交（51.8％），但各组之间无显着差异。在参与者的梅毒史（P = .030），在阿姆斯特丹一个受欢迎的性爱场所遇见伴侣（P = .048），在阿姆斯特丹以外会见伴侣（P = .036）方面，发现了参与者之间的重大差异（P = .030）。高危MSM人群中存在传播网络;存在集群和流行病学特征之间的一致性，但是没有明显的一致性。

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