• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Heliyon >Bioautography and GC-MS based identification of piperine and trichostachine as the active quorum quenching compounds in black pepper
【2h】

Bioautography and GC-MS based identification of piperine and trichostachine as the active quorum quenching compounds in black pepper

机译：基于生物自显影和GC-MS的胡椒碱和trichostachine鉴定为黑胡椒中有效的群体猝灭化合物

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the search of new and safe antibacterial compounds, the quorum sensing system (QS) modulation by natural products has been studied. As a result, many plant-derived compounds have been identified as potent quorum sensing inhibitors. L. (black pepper) ethanolic extract inhibits the QS in some Gram-negative bacteria but the active components have not been previously identified. Thus, the objective of this work was to identify the peppercorns main components that block the QS, applying bioassay and chromatographic techniques. Piperine and trichostachine were identified as the main components responsible for the quorum quenching (QQ) activity of peppercorns extract. Piperine at 30 mg/L, decreased the violacein production by CV026 by 35%, without affecting bacterial growth. Piperine concentration of 40 mg/L decreases violacein production by CV026 by 70% and growth in only 4.34%. Trichostachine at 50 mg/L decreases violacein production by CV026 by 12%, without affecting bacterial growth. xtract concentration of 0.5 g/L decreased violacein production in 40 % and no effects on growth were observed. Neither extract, piperine, nor trichostachine did affect QS of PAO1. Data here described exhibit the potential of piperamides as modulators of QS, not previously reported.
机译：在寻找新型和安全的抗菌化合物时，已经研究了天然产物对群体感应系统（QS）的调节作用。结果，许多植物来源的化合物已被鉴定为有效的群体感应抑制剂。 L.（黑胡椒）乙醇提取物可抑制某些革兰氏阴性细菌的QS，但以前尚未确定其活性成分。因此，这项工作的目的是利用生物测定和色谱技术，确定阻碍QS的花椒的主要成分。胡椒碱和trichostachine被确定为负责胡椒提取物的群体猝灭（QQ）活性的主要成分。浓度为30 mg / L的胡椒碱可将CV026的紫胶素产量降低35％，而不会影响细菌的生长。胡椒碱浓度为40 mg / L时，CV026的紫胶素产量降低70％，而增幅仅为4.34％。浓度为50 mg / L的Trichostachine可将CV026的紫胶生成减少12％，而不会影响细菌的生长。浓度为0.5 g / L的xtract降低了40％的紫胶素产量，未观察到对生长的影响。提取物，胡椒碱或曲古茶碱均未影响PAO1的QS。此处描述的数据显示出哌啶具有作为QS调节剂的潜力，以前没有报道过。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号