Analysis of Protein Conformational Strains—A Key for New Diagnostic Methods of Human Diseases

机译：蛋白质构象菌株分析—人类疾病新诊断方法的关键

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

α-Synuclein is a naturally unfolded protein which easily aggregates and forms toxic inclusions and deposits. It is associated with several neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases, called synucleinopathies, have overlapping symptoms but require different methods of treatment. There are no reliable approaches for early diagnoses of these diseases, and as a result, the treatment begins late, and the disorders are often misdiagnosed. Recent studies revealed that α-synuclein forms distinctive spatial structures or strains at the early steps of these diseases, which may be used for early diagnosis. One of these early diagnostic methods called PMCA (protein misfolding cyclic amplification) allows identification of the distinct α-synuclein strains specific for different human diseases. The method is successfully used for differential diagnosis of patients with PD and MSA.

机译：α-突触核蛋白是一种天然展开的蛋白质，易于聚集并形成有毒的内含物和沉积物。它与多种神经退行性疾病有关，包括帕金森氏病（PD），路易体痴呆（DLB）和多系统萎缩（MSA）。这些被称为突触核病的疾病具有重叠的症状，但需要不同的治疗方法。没有可靠的方法可以对这些疾病进行早期诊断，结果，治疗开始得很晚，而且常常会误诊这些疾病。最近的研究表明，α-突触核蛋白在这些疾病的早期阶段形成独特的空间结构或菌株，可用于早期诊断。这些称为PMCA（蛋白质错误折叠循环扩增）的早期诊断方法之一，可以鉴定出针对不同人类疾病的独特α-突触核蛋白菌株。该方法已成功用于PD和MSA患者的鉴别诊断。

著录项

期刊名称 International Journal of Molecular Sciences
作者
Andrei Surguchov;
展开▼
作者单位

展开▼
年(卷),期 2020(21),8
年度 2020
页码 -1
总页数 5
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Parkinson’s disease; multiple system atrophy; α-synuclein; conformational diseases; protein misfolding cyclic amplification;

机译：帕金森氏病;多系统萎缩;α-突触核蛋白;构象性疾病;蛋白质错折叠循环扩增;

相似文献

外文文献
中文文献
专利

1. Comparative analysis of the methods of drug and protein delivery for the treatment of cancer, genetic diseases and diagnostics [J] . TodorovaR. Drug delivery. . 2011,第8期

机译：药物和蛋白质递送方法在癌症，遗传性疾病和诊断方法中的比较分析
2. Comparative analysis of the methods of drug and protein delivery for the treatment of cancer, genetic diseases and diagnostics [J] . Roumiana Todorova Drug delivery. . 2011,第8期

机译：药物和蛋白质递送方法在癌症，遗传性疾病和诊断方法中的比较分析
3. Image Processing and Analysis in Diagnostics and Radiotherapy of Thyroid Gland Diseases: Problems, Approaches, and Methods [J] . A. F. Tsyb, R. A. Roziev, A. N. Klepov, Pattern recognition and image analysis: advances in mathematical theory and applications in the USSR . 2001,第2期

机译：甲状腺疾病的诊断和放射治疗中的图像处理和分析：问题，方法和方法
4. Sensors for Breath Analysis: An Advanced Approach to Express Diagnostics and Monitoring of Human Diseases [C] . I.G. Kushch, N.M. Korenev, L.V. Kamarchuk, NATO Advanced Study Institute on Biodefence: Advanced materials and methods for health protection . 2011

机译：呼吸分析的传感器：表达诊断和监测人类疾病的先进方法
5. Lymphoproliferative disease virus (LPDV) in wild turkeys (Meleagris gallopavo) in New York state: diagnostic methods, prevalence, and spatial distribution of a newly discovered pathogen [D] . Alger, Katrina E. 2015

机译：纽约州野生火鸡（Meleagris gallopavo）的淋巴增生病病毒（LPDV）：新发现病原体的诊断方法，患病率和空间分布
6. Helminth parasites of howler and spider monkeys in Mexico: Insights into molecular diagnostic methods and their importance for zoonotic diseases and host conservation [O] . Brenda Solórzano-García, Gerardo Pérez-Ponce de León 2017

机译：墨西哥how猴和蜘蛛猴的寄生虫：分子诊断方法及其对人畜共患病和寄主保护的重要性
7. ABSTRACT Various body parts or organs can be analysed to identify the different diseases in the human body. Fingernail analysis is one of the ways to identify disease in the human body. Nails are the body part which are farthest from the heart and therefore receive oxygen at last. As a result the nails are the first who show the symptoms of a disease in the human body. Fingernails can be easily captured for diagnosis and there are no heavy equipment or no specific conditions required to use nail image for disease diagnosis, like in other tests and scanning processes. Human nails deliver beneficial information about complaints or any nutritive imbalances in the human body depending upon their shape, texture and colour. In human beings, numerous systemic and skin diseases can be easily analyzed through careful examination of nails of both the limbs. A lot of nail illnesses have been found to be primary signs of numerous underlying systemic illnesses. The colour, texture or shape changes in nails are signs of many diseases mainly affecting nails. Considering all these properties of nails a system is proposed that uses digital image processing (DIP) methods for identifying such changes in the human nail to get more precise results and predict numerous diseases effortlessly. With the emerging Internet of Things (IOT) concept the generated report is made available remotely, this will help users to reduce transportation efforts. As the system has to deal with large and private data, the security of data must be ensured. To keep the data confidential, the Blockchain concept which is one of the most emerging concepts in the field of data management is used. The paper contains the implementation of the digital image processing for feature extraction of nail images, usage of IOT (ThingSpeak cloud) for data storage and implementation of Blockchain to keep the system secured and theft free. KEY WORDS: Int ernet of thin gs (IOT), Image proc essin g, Thin gSpeak, RG B vavalues, Mean pi xel vavalues, Bloc kchain , Hash key. Disease Diagnostic System: Abnormalities in Human Nail [O] . Pranav S. Wazarkar 2020

机译：摘要的各个身体部位或器官可被分析以识别在人体内的不同的疾病。指甲分析来识别人体疾病的方法之一。指甲是身体一部分是离心脏最远，因此在最后接受氧气。作为结果，指甲是第一谁表现出人体疾病的症状。指甲可以容易地捕获用于诊断和没有重装或需要使用指甲图像用于疾病诊断，比如在其他测试和扫描过程没有特定的条件。人的指甲提供有关投诉或取决于它们的形状，纹理和色彩在人体内的任何营养失衡有益的信息。在人类中，许多全身性皮肤疾病是可以很容易地通过两个四肢指甲的仔细检查分析。很多指甲病已发现众多潜在系统性疾病的主要症状。在指甲的颜色，质地和形状的变化是许多疾病主要影响指甲的迹象。考虑到所有的指甲的这些性能的系统被提出，用于识别人指甲这样的变化以获得更精确的结果，并毫不费力预测许多疾病用途的数字图像处理（DIP）方法。随着物联网（IOT）的概念，新兴的互联网将生成的报告提供远程，这将帮助用户降低运输工作。由于系统必须处理大量的私人数据，数据的安全性必须得到保证。为了保持数据的机密性，使用Blockchain的概念，它是在数据管理领域的大多数新兴的概念之一。本文包含了数字图像处理的指甲图像，IOT（ThingSpeak云）的使用为数据存储和执行Blockchain的特征提取的执行，以保持固定的系统和盗窃免费。关键词：诠释薄GS（IOT），图像的ERNET PROC essin克，薄型gSpeak，RG乙vavalues，平均数PI XEL vavalues，阵营kchain，哈希密钥。疾病诊断系统：在人类指甲异常

Analysis of Protein Conformational Strains—A Key for New Diagnostic Methods of Human Diseases

摘要

著录项

相似文献

相关主题

期刊订阅