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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >How Birth Season Affects Vulnerability to the Effect of Ambient Ozone Exposure on the Disease Burden of Hypertension in the Elderly Population in a Coastal City in South China
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How Birth Season Affects Vulnerability to the Effect of Ambient Ozone Exposure on the Disease Burden of Hypertension in the Elderly Population in a Coastal City in South China

机译：出生季节如何影响环境臭氧暴露对华南沿海城市老年人口高血压疾病负担的影响

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Birth season is an important factor that reflects prenatal nutritional conditions during early development, and which might have lifelong impacts on health. Moreover, ambient ozone pollution has been considered an important environmental risk factor for hypertension. However, whether birth season affects vulnerability to the effect of ambient ozone exposure on late-life hypertension is still unknown. A flexible case–crossover design was used to explore the effect of ambient ozone exposure on the disease burden of hypertension using years of life lost (YLL) in the elderly population in a coastal city in South China from 2013 to 2016. The influence of birth season was also explored. Ozone exposure was significantly associated with increased YLL from hypertension. The association was higher in the elderly individuals who were born in autumn than in those born in other seasons. Specifically, every 10 μg/m increase in ozone was associated with 0.68 (95% CI: 0.27, 1.10) YLL from hypertension in the elderly population born in autumn, while nonsignificant associations were found for those born in other seasons. The birth season, which affects the nutritional condition during early development, could affect vulnerability to the effect of ambient ozone exposure on the disease burden of hypertension in late life. The findings highlighted the importance of taking birth season into consideration when exploring the hypertensive effects of ozone exposure.
机译：出生季节是一个重要因素，它反映了早期发育期间的产前营养状况，并且可能对健康产生终身影响。此外，环境臭氧污染被认为是高血压的重要环境危险因素。但是，出生季节是否会影响环境臭氧暴露对晚年高血压的影响尚不明确。使用灵活的病例交叉设计，通过2013年至2016年华南沿海城市老年人口的多年寿命损失（YLL），探索了环境臭氧暴露对高血压疾病负担的影响。出生的影响季节也进行了探索。臭氧暴露与高血压引起的YLL升高显着相关。秋季出生的老年人的关联性高于其他季节出生的老年人。具体来说，在秋季出生的老年人口中，每增加10μg/ m的臭氧，就会导致高血压产生0.68（95％CI：0.27，1.10）的YLL，而在其他季节出生的老年人则无显着相关性。出生季节会影响早期发育期间的营养状况，可能会影响到环境臭氧暴露对晚年高血压疾病负担的影响的脆弱性。研究结果突显了在探索臭氧暴露的高血压影响时考虑出生季节的重要性。

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