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首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Pathology >The expressions of YAP1 β-catenin and survivin in colon cancer tissues and their clinical significance
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The expressions of YAP1 β-catenin and survivin in colon cancer tissues and their clinical significance

机译：YAP1β-catenin和survivin在结肠癌组织中的表达及其临床意义

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We aimed to evaluate the effects of YAP1, β-catenin, and survivin on the onset and progression of colon cancer, and to explore their correlations. The expressions of YAP1, β-catenin, and survivin in 106 colon cancer tissues and 55 normal colon mucosa tissues were measured by immunohistochemical assay. The correlations between their expressions and clinical and pathological characteristics were analyzed. The expression rates of YAP1, β-catenin, and survivin in colon cancer tissues were significantly higher than those in normal colon mucosa tissues (P<0.001). The expressions of YAP1, β-catenin, and survivin in colon cancer were correlated with neither gender nor age (P>0.05), but with the degree of differentiation, depth of invasion, lymph node metastasis and Duke’s stage (P<0.05). Pearson’s correlation analysis showed that the expressions of YAP1, β-catenin, and survivin in colon cancer tissues were all positively correlated (P<0.05). The overexpression of YAP1, β-catenin, and survivin played an important role in the onset and progression of colon cancer, providing reference value for prognosis prediction.
机译：我们旨在评估YAP1，β-catenin和survivin对结肠癌的发生和发展的影响，并探讨它们之间的相关性。免疫组化法检测106例结肠癌组织和55例正常结肠黏膜组织中YAP1，β-catenin和survivin的表达。分析了它们的表达与临床和病理特征之间的相关性。结肠癌组织中YAP1，β-catenin和survivin的表达率明显高于正常结肠黏膜组织（P <0.001）。结肠癌中YAP1，β-catenin和survivin的表达与性别和年龄均无关（P> 0.05），但与分化程度，浸润深度，淋巴结转移和杜克分期有关（P <0.05）。皮尔逊相关分析表明，结肠癌组织中YAP1，β-catenin和survivin的表达均呈正相关（P <0.05）。 YAP1，β-catenin和survivin的过度表达在结肠癌的发生和发展中起重要作用，为预后预测提供参考。

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