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首页> 美国卫生研究院文献>Materials >Effect of the Compositions on the Biocompatibility of New Alumina–Zirconia–Titania Dental Ceramic Composites
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Effect of the Compositions on the Biocompatibility of New Alumina–Zirconia–Titania Dental Ceramic Composites

机译：组成对新型氧化铝-氧化锆-二氧化钛牙科陶瓷复合材料生物相容性的影响

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Dental implant biomaterials are expected to be in contact with living tissues, therefore their toxicity and osseointegration ability must be carefully assessed. In the current study, the wettability, cytotoxicity, and genotoxicity of different alumina–zirconia–titania composites were evaluated. The surface wettability determines the biological event cascade in the bioceramic/human living tissues interface. The measured water contact angle indicated that the wettability strongly depends on the ceramic composition. Notwithstanding the contact angle variability, the ceramic surfaces are hydrophilic. The cytotoxicity of human gingival fibroblast cells with materials, evaluated by an (3-(4,5 methylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) test, revealed an absence of any cytotoxic effect. A relationship was found between the cell viability and the wettability. It was subsequently deduced that the cell viability increases when the wettability increases. This effect is more pronounced when the titania content is higher. Finally, a comet test was applied as complementary biocompatibility test to detect any changes in fibroblast cell DNA. The results showed that the DNA damage is intimately related to the TiO content. Genotoxicity was mainly attributed to ceramic composites containing 10 wt.% TiO . Our research revealed that the newly developed high performance alumina–zirconia–titania ceramic composites contain less than 10 wt.% TiO , and display promising surface properties, making them suitable for dental implantology applications.
机译：牙科植入物生物材料有望与活组织接触，因此必须仔细评估其毒性和骨整合能力。在当前的研究中，评估了不同氧化铝-氧化锆-二氧化钛复合材料的润湿性，细胞毒性和遗传毒性。表面润湿性决定了生物陶瓷/人活组织界面中的生物事件级联。测得的水接触角表明润湿性在很大程度上取决于陶瓷组成。尽管接触角是可变的，但陶瓷表面还是亲水的。用（3-（4,5甲基噻唑-2-基）-2,5-二苯基溴化四唑鎓（MTT）试验评估的材料对人牙龈成纤维细胞的细胞毒性表明没有任何细胞毒性作用。在细胞活力和润湿性之间发现，随后推论说，随着润湿性的增加，细胞活力增加；当二氧化钛含量更高时，这种影响更加明显；最后，彗星试验被用作补充生物相容性试验以检测结果表明，DNA损伤与TiO含量密切相关；基因毒性主要归因于TiO 2含量为10 wt。％的陶瓷复合材料；我们的研究表明，新开发的高性能氧化铝-氧化锆-二氧化钛陶瓷该复合材料包含少于10 wt。％的TiO，并且显示出有希望的表面性能，使其适合牙科种植应用。

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