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Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid Cellulose and Etamsylate

机译：透明质酸纤维素和氨酯基复合止血非织造布

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The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds ( < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.
机译：快速止血的成就代表了止血研究的长期趋势。具体而言，基于给定的问题和所需的性能，复合材料现在已成为关注的焦点。在泌尿科，使用不同的材料来实现快速有效的止血。另外，期望对局部组织反应产生积极影响。在这项研究中，引入了三种通过湿纺方法制备的非织造织物，并以透明质酸与氧化纤维素或羧甲基纤维素的混合物为基础，并添加了依他木酸酯，并使用大鼠部分肾切除模型在体内进行了评估。由于羧甲基纤维素材料的作用，止血时间明显缩短（以秒为单位）（<0.05）。依坦沙酯的添加并未明显促进进一步止血，但其应用增强了结构，因此显着改善了局部改变的效果，同时也便于外科医生进行任何操作。具体而言，透明质酸支持组织的愈合和再生，并确保组织学分析的良好结果。此外，制备的纺织品在三天后证明了其生物吸收性。简而言之，该织物具有良好的止血活性，生物吸收性，非刺激性，并且对组织修复具有有益的作用。

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