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首页> 美国卫生研究院文献>Microbial Genomics >Comparative genomics of the fish pathogens Edwardsiella ictaluri 93-146 and Edwardsiella piscicida C07-087
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Comparative genomics of the fish pathogens Edwardsiella ictaluri 93-146 and Edwardsiella piscicida C07-087

机译：鱼病原体爱德华氏菌93-146和比氏爱德华氏菌C07-087的比较基因组学

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摘要

and are important fish pathogens affecting cultured and wild fish worldwide. To investigate the genome-level differences and similarities between catfish-adapted strains in these two species, the complete 93-146 and  C07-087 genomes were evaluated by applying comparative genomics analysis. All available complete (10) and non-complete (19) genomes from five species were also included in a systematic analysis. Average nucleotide identity and core-genome phylogenetic tree analyses indicated that the five species were separated from each other. Pan-/core-genome analyses for the 29 strains from the five species showed that genus members have 9474 genes in their pan genome, while the core genome consists of 1421 genes. Orthology cluster analysis showed that and  genomes have the greatest number of shared clusters. However, and  also have unique features; for example, the genome encodes urease enzymes and cytochrome o ubiquinol oxidase subunits, whereas  genomes encode tetrathionate reductase operons, capsular polysaccharide synthesis enzymes and vibrioferrin-related genes. Additionally, we report for what is believed to be the first time that 93-146 and three other genomes encode a type IV secretion system (T4SS), whereas none of the  genomes encode this system. Additionally, the  C07-087 genome encodes two different type VI secretion systems. genomes tend to encode more insertion elements, phage regions and genomic islands than . We speculate that the T4SS could contribute to the increased number of mobilome elements in compared to . Two of the  genomes encode full CRISPR-Cas regions, whereas none of the genomes encode Cas proteins. Overall, comparison of the and  genomes reveals unique features and provides new insights on pathogenicity that may reflect the host adaptation of the two species.
机译：是影响全世界养殖和野生鱼类的重要鱼类病原体。为了研究这两个物种的cat鱼适应菌株之间的基因组水平差异和相似性，通过应用比较基因组学分析评估了完整的93-146和C07-087基因组。系统分析还包括来自五个物种的所有可用完整（10个）和不完整（19个）基因组。平均核苷酸同一性和核心基因组系统树分析表明，这五个物种彼此分离。对五个物种的29个菌株的泛/核心基因组分析表明，属成员的泛基因组中有9474个基因，而核心基因组由1421个基因组成。正交聚类分析表明，和基因组具有最多的共享聚类。但是，和也具有独特的功能;例如，基因组编码尿素酶和细胞色素o泛醇氧化酶亚基，而基因组编码四硫酸盐还原酶操纵子，荚膜多糖合成酶和弧菌铁蛋白相关基因。此外，我们报道了93-146和其他三个基因组首次编码IV型分泌系统（T4SS）的报道，而所有基因组均未编码该系统。此外，C07-087基因组编码两个不同的VI型分泌系统。基因组往往比编码更多的插入元件，噬菌体区域和基因组岛。我们推测，与相比，T4SS可能有助于增加活动单元的数量。两个基因组编码完整的CRISPR-Cas区，而没有一个基因组编码Cas蛋白。总的来说，基因组和基因组的比较揭示了独特的功能，并提供了有关致病性的新见解，可能反映了两种物种的宿主适应性。

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