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首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Contribution of the BacT/Alert MB Mycobacterium Bottle to Bloodstream Infection Surveillance in Thailand: Added Yield for Burkholderia pseudomallei
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Contribution of the BacT/Alert MB Mycobacterium Bottle to Bloodstream Infection Surveillance in Thailand: Added Yield for Burkholderia pseudomallei

机译：BacT / Alert MB分枝杆菌瓶对泰国血流感染监测的贡献：假伯克霍尔德菌的增产

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Community-acquired bloodstream infections cause substantial morbidity and mortality worldwide, but microbiology capacity and surveillance limitations have challenged good descriptions of pathogen distribution in many regions, including Southeast Asia. Active surveillance for bloodstream infections has been conducted in two rural Thailand provinces for >7 years. Blood specimens were divided into two culture bottles, one optimized for aerobic growth (F bottle) and a second for enhanced growth of mycobacteria (MB bottle), and processed with the BactT/Alert 3D system. Because the routine use of MB culture bottles is resource intensive (expensive and requires prolonged incubation), we assessed the added yield of MB bottles by comparing the proportion of pathogens detected by MB versus that by F bottles from 2005 to 2012. Of 63,066 blood cultures, 7,296 (12%) were positive for at least one pathogen; the most common pathogens were Escherichia coli (28%), Burkholderia pseudomallei (11%), Klebsiella pneumoniae (9%), and Staphylococcus aureus (6%). Two bottles improved the yield overall, but the added yield attributable to the MB bottles was limited to a few pathogens. In addition to the detection of mycobacteria and some fungi, MB bottles improved the detection of B. pseudomallei (27% [MB] versus 8% [F]; P < 0.0001), with added benefit if therapy was initiated prior to the blood culture. The targeted use of MB bottles is warranted for patients at risk for mycobacterial and fungal infections and for infection with B. pseudomallei, a common cause of septicemia in Thailand.
机译：社区获得性血流感染在全世界范围内引起大量发病和死亡，但是微生物学能力和监测限制已经挑战了对包括东南亚在内的许多地区病原体分布的良好描述。在泰国的两个农村省份，对血液感染的主动监测已经进行了超过7年。将血液样本分为两个培养瓶，一个用于有氧生长的优化培养瓶（F瓶），另一个用于增强分枝杆菌生长的培养瓶（MB瓶），并用BactT / Alert 3D系统处理。由于MB培养瓶的常规使用会占用大量资源（昂贵且需要长时间孵育），因此我们通过比较2005年至2012年MB检测的病原体与F瓶检测到的病原体的比例，评估了MB瓶的增产。63,066份血液培养物中，其中至少一种病原体为7,296（12％）阳性；最常见的病原体是大肠杆菌（28％），假伯克霍尔德菌（11％），肺炎克雷伯菌（9％）和金黄色葡萄球菌（6％）。两个瓶子总体上提高了产量，但可归因于MB瓶子的增加的产量仅限于少数病原体。除了检测分枝杆菌和某些真菌外，MB瓶还改善了假苹果芽孢杆菌的检测（27％[MB]对8％[F]； P <0.0001），如果在血培养之前开始治疗，则还有更多好处。 。 MB瓶有针对性地用于有分枝杆菌和真菌感染风险的人，以及感染泰国败血病的常见病原假芽孢杆菌的患者。

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