• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Nutrients >Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink?
【2h】

Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink?

机译：非酒精性脂肪性肝病的中度饮酒：喝还是不喝？

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nonalcoholic fatty liver disease (NAFLD) is defined by hepatic steatosis in the presence of alcohol intake within safe limits, defined by guidelines of scientific associations (usually 20 g or 2 units/day in women, 30 g or 3 units in men). The diagnosis is usually followed by medical counseling of total abstinence, in order to prevent disease progression. This policy has been challenged by epidemiological studies, suggesting that the risk of liver disease and disease progression is lower in modest drinkers than in total abstainers. We revised the literature on the effects of modest alcohol intake on disease burden. Epidemiological data may suffer from several potential biases (recall bias for retrospective analyses, difficulties in the calculation of g/day), limiting their validity. Prospective data suggest that NAFLD patients with regular alcohol intake, although within the safe thresholds, are at higher risk of liver disease progression, including hepatocellular carcinoma; a detrimental effect of modest alcohol drinking is similarly observed in liver disease of viral etiology. Alcohol intake is also a risk factor for extrahepatic cancers, particularly breast, oral, and pharyngeal cancers, with gender difference and no floor effect, which outweigh the possible beneficial effects on cardiovascular system, also derived from retrospective studies. Finally, the negative effects of the calorie content of alcohol on dietary restriction and weight loss, the pivotal intervention to reduce NAFLD burden, should be considered. In summary, the policy of counseling NAFLD patients for alcohol abstinence should be maintained.
机译：非酒精性脂肪性肝病（NAFLD）的定义是，在科学限度的指导下（在女性中通常为20 g或2单位/天，在男性中通常为30 g或3单位），在安全摄入范围内存在酒精摄入的情况下发生肝脂肪变性。在诊断之后通常会进行完全戒断的医学咨询，以防止疾病进展。这项政策已受到流行病学研究的挑战，表明适度饮酒者的肝脏疾病风险和疾病进展风险低于完全戒酒者。我们修订了有关适量饮酒对疾病负担影响的文献。流行病学数据可能会遭受多种潜在偏见（回顾性分析的召回偏见，克/天的计算困难），从而限制了其有效性。前瞻性数据表明，定期饮酒的NAFLD患者尽管在安全阈值之内，但肝脏疾病进展的风险较高，包括肝细胞癌。在病毒病因性肝病中类似地观察到适度饮酒的有害作用。饮酒也是肝外癌症的危险因素，尤其是乳腺癌，口腔癌和咽喉癌，其性别差异无底效，这超过了对心血管系统的可能有益作用，这也来自回顾性研究。最后，应考虑酒精中卡路里含量对饮食限制和减肥的负面影响，这是减轻NAFLD负担的关键干预措施。总之，应维持对NAFLD患者进行戒酒咨询的政策。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号