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首页> 美国卫生研究院文献>Pharmaceutics >Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives
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Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives

机译：鼻腔给药的脂质体配方：最新进展和未来展望

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摘要

Restricted drug entry to the brain that is closely associated with the existence of the blood brain barrier (BBB) has limited the accessibility of most potential active therapeutic compounds to the brain from the systemic circulation. Recently, evidences for the presence of direct nose-to-brain drug transport pathways have been accumulated by several studies and an intranasal drug administration route has gained attention as a promising way for providing direct access to the brain without the needs to cross to the BBB. Studies aiming for developing nanoparticles as an intranasal drug carrier have shown considerable promise in overcoming the challenges of intranasal drug delivery route. This review gives a comprehensive overview of works having investigated liposomes as a potential vehicle to deliver drugs to the brain through nose-to-brain route while considering the excellent biocompatibility and high potential of liposomes for clinical development. Herein, studies are reviewed with special emphasis on the impact of formulation factors, such as liposome composition and surface modification of liposomes with targeting moieties, in addition to intranasal environmental factors that may affect the extent/site of absorption of intranasally administered, liposome-encapsulated drugs.
机译：与血脑屏障（BBB）的存在密切相关的受限药物进入大脑限制了大多数潜在活性治疗化合物从全身循环进入大脑的可及性。最近，一些研究已经积累了直接的鼻-脑药物转运途径的证据，并且鼻内给药途径已成为一种有希望的途径，可以直接进入大脑而不需要穿越血脑屏障，因此受到了关注。 。旨在开发纳米颗粒作为鼻内药物载体的研究在克服鼻内药物输送途径的挑战方面显示出巨大的希望。这篇综述对研究脂质体作为通过鼻-脑途径向大脑输送药物的潜在载体进行了全面综述，同时考虑了脂质体的优异生物相容性和临床开发的高潜力。本文中，除鼻内环境因素可能会影响鼻内给药，脂质体包裹的吸收程度/部位外，研究特别强调了制剂因素的影响，例如脂质体组成和具有靶向部分的脂质体的表面修饰毒品。

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