PNAS Plus: Crystal structures of Ca2+–calmodulin bound to NaV C-terminal regions suggest role for EF-hand domain in binding and inactivation

机译：PNAS Plus：与NaV C端区域结合的Ca2 + –钙调蛋白的晶体结构表明EF手结构域在结合和失活中的作用

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
Bernd R. Gardill; Ricardo E. Rivera-Acevedo; Ching-Chieh Tung; Filip Van Petegem;
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作者单位

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年(卷),期 2019(116),22
年度 2019
页码 -1
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
sodium channel; inactivation; cardiac arrhythmia; long-QT syndrome; calcium-dependent inactivation;

机译：钠通道失活;心律失常;长QT综合征;钙依赖性失活;

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专利

1. On the Ca2+ binding and conformational change in EF-hand domains: Experimental evidence of Ca2+-saturated intermediates of N-domain of calmodulin [J] . Ababou Abdessamad, Zaleska Mariola, Pfuhl Mark Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2017,第6期

机译：在EF手域的CA2 +结合和构象变化：钙调蛋白N-结构域的CA2 + - 饱和中间体的实验证据
2. Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+?Calmodulin Displays a Unique Binding Mode [J] . Yanshun Liu, Xunhai Zheng, Geoffrey Mueller, The Journal of biological chemistry . 2012,第51期

机译：钙调蛋白结合结构域的钙调平素与Ca2 +α的钙调介素结合结构域的晶体结构显示出独特的绑定模式
3. Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin [J] . Chaojian Wang, Ben C. Chung, Haidun Yan, Structure . 2012,第7期

机译：NaV C末端域，成纤维细胞生长因子同源因子和钙调蛋白三元复合物的晶体结构
4. BARLEY OC-AMYLASE ISOZYME 3D STRUCTURES AT WORK REVEAL REMARKABLE DIFFERENCES AND A NOVEL ROLE OF THEIR C-TERMINAL DOMAIN [C] . Xavier Robert, Richard Baser, Birte Svensson, European Symposium on Enzymes in Grain Processing . 2003

机译：大麦Oc-amylase Isozyme 3D结构在工作中显示出显着的差异和它们的C末端结构域的新颖作用
5. The Role of EF-Hand in Calmodulin Binding of Voltage-Gated Cav2.1 and Cav2.2 Calcium Channels [D] . Soh, Daniel Hyeongjin. 2018

机译：EF手在电压门控Cav2.1和Cav2.2钙通道的钙调蛋白结合中的作用
6. Crystal structure of the ternary complex of a NaV C-terminal domain a fibroblast growth factor homologous factor and calmodulin [O] . Chaojian Wang, Ben C. Chung, Haidun Yan, -1

机译：一个导航C末端结构域成纤维细胞生长因子同源因子和calmodulin的三元复合物的晶体结构
7. NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD [O] . Ryan Mahling, Liam Hovey, Holly M. Isbell, 2021

机译：Nav1.2 EFL域构成增强与WT和致病性钙调蛋白突变体与通道CTD结合的致病成分突变体的Ca2 +结合

PNAS Plus: Crystal structures of Ca2+–calmodulin bound to NaV C-terminal regions suggest role for EF-hand domain in binding and inactivation

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