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首页> 美国卫生研究院文献>The World Allergy Organization Journal >The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources
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The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources

机译：室内过敏原来源的单个IgE抗体结合分子的过敏活性和临床影响

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A large number of allergens have been discovered but we know little about their potential to induce inflammation (allergenic activity) and symptoms. Nowadays, the clinical importance of allergens is determined by the frequency and intensity of their IgE antibody binding (allergenicity). This is a rather limited parameter considering the development of experimental allergology in the last 20 years and the criteria that support personalized medicine. Now it is known that some allergens, in addition to their IgE antibody binding properties, can induce inflammation through non IgE mediated pathways, which can increase their allergenic activity. There are several ways to evaluate the allergenic activity, among them the provocation tests, the demonstration of non-IgE mediated pathways of inflammation, case control studies of IgE-binding frequencies, and animal models of respiratory allergy. In this review we have explored the current status of basic and clinical research on allergenic activity of indoor allergens and confirm that, for most of them, this important property has not been investigated. However, during recent years important advances have been made in the field, and we conclude that for at least the following, allergenic activity has been demonstrated: Der p 1, Der p 2, Der p 5 and Blo t 5 from HDMs; Per a 10 from ; Asp f 1, Asp f 2, Asp f 3, Asp f 4 and Asp f 6 from ; Mala s 8 and Mala s 13 from ; Alt a 1 from ; Pen c 13 from ; Fel d 1 from cats; Can f 1, Can f 2, Can f 3, Can f 4 and Can f 5 from dogs; Mus m 1 from mice and Bos d 2 from cows. Defining the allergenic activity of other indoor IgE antibody binding molecules is necessary for a precision-medicine-oriented management of allergic diseases.
机译：已经发现了大量的过敏原，但我们对其诱发炎症（过敏原活性）和症状的潜力知之甚少。如今，变应原的临床重要性取决于其IgE抗体结合的频率和强度（变应原性）。考虑到最近20年来实验性变态反应学的发展以及支持个性化医学的标准，这是一个相当有限的参数。现在已知，某些过敏原除具有IgE抗体结合特性外，还可以通过非IgE介导的途径诱导炎症，从而增加其过敏原活性。有几种评估变应原活性的方法，包括激发试验，非IgE介导的炎症途径的证明，IgE结合频率的病例对照研究以及呼吸道过敏的动物模型。在这篇综述中，我们探讨了室内变应原致敏活性的基础和临床研究的现状，并确认对于大多数变应原来说，这一重要特性尚未得到研究。然而，近年来，该领域取得了重要进展，并且我们得出的结论是，至少对于以下方面，已证明了致敏活性：HDM的Der p 1，Der p 2，Der p 5和Blo t 5；每10个起; Asp f 1，Asp f 2，Asp f 3，Asp f 4和Asp f 6；马拉8和马拉13来自;替代1;笔c 13从;从猫处获得d 1；犬的can 1，can 2，can 3，can 4和can 5小鼠的Mus m 1和牛的Bos d 2。定义其他室内IgE抗体结合分子的变应原活性对于精确医学导向的变应性疾病管理是必不可少的。

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