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A Meta‐analysis on the neural basis of planning: Activation likelihood estimation of functional brain imaging results in the Tower of London task

机译:基于规划的神经基础的元分析:伦敦塔任务中功能性脑成像的激活可能性估计

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摘要

The ability to mentally design and evaluate series of future actions has often been studied in terms of planning abilities, commonly using well‐structured laboratory tasks like the Tower of London (ToL). Despite a wealth of studies, findings on the specific localization of planning processes within prefrontal cortex (PFC) and on the hemispheric lateralization are equivocal. Here, we address this issue by integrating evidence from two different sources of data: First, we provide a systematic overview of the existing lesion data on planning in the ToL (10 studies, 211 patients) which does not indicate any evidence for a general lateralization of planning processes in (pre)frontal cortex. Second, we report a quantitative meta‐analysis with activation likelihood estimation based on 31 functional neuroimaging datasets on the ToL. Separate meta‐analyses of the activation patterns reported for (537 participants) and for (182 participants) congruently show bilateral contributions of mid‐dorsolateral PFC, frontal eye fields, supplementary motor area, precuneus, caudate, anterior insula, and inferior parietal cortex in addition to a left‐lateralized involvement of rostrolateral PFC. In contrast to previous attributions of planning‐related brain activity to the entire dorsolateral prefrontal cortex (dlPFC) and either its left or right homolog derived from single studies on the ToL, the present meta‐analyses stress the pivotal role specifically of the mid‐dorsolateral part of PFC (mid‐dlPFC), presumably corresponding to Brodmann Areas 46 and 9/46, and strongly argue for a bilateral rather than lateralized involvement of the dlPFC in planning in the ToL. . ©
机译:人们通常根据规划能力来研究在心理上设计和评估一系列未来行动的能力,通常使用结构良好的实验室任务,例如伦敦塔(ToL)。尽管进行了大量研究,但关于前额叶皮层(PFC)内计划过程的特定定位以及半球侧向化的发现是模棱两可的。在这里,我们通过整合来自两个不同数据来源的证据来解决该问题:首先,我们提供了有关ToL中计划中的现有病变数据的系统概述(10项研究,211例患者),但并未提供任何证据表明总体偏侧化(前)额叶皮层的计划过程。其次,我们基于ToL上的31个功能性神经影像数据集,报告了具有激活可能性估计的定量荟萃分析。分别对(537名参与者)和(182名参与者)报道的激活模式进行了荟萃分析,这些结果均显示了中背外侧PFC,额叶视野,辅助运动区,前突,尾状,前岛和顶下皮质的双边贡献。除了左外侧累及后外侧PFC。与以前计划相关的大脑活动归因于整个背外侧前额叶皮层(dlPFC)及其从ToL的单项研究得出的左或右同源物不同,本荟萃分析强调了特定于背外侧中枢的关键作用PFC(mid-dlPFC)的一部分,大概对应于Brodmann Areas 46和9/46,并强烈主张dlPFC在ToL规划中是双边参与而不是横向参与。 。 ©

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