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首页> 美国卫生研究院文献>EFSA Journal >Re‐evaluation of oxidised starch (E 1404) monostarch phosphate (E 1410) distarch phosphate (E 1412) phosphated distarch phosphate (E 1413) acetylated distarch phosphate (E 1414) acetylated starch (E 1420) acetylated distarch adipate (E 1422) hydroxypropyl starch (E 1440) hydroxypropyl distarch phosphate (E 1442) starch sodium octenyl succinate (E 1450) acetylated oxidised starch (E 1451) and starch aluminium octenyl succinate (E 1452) as food additives
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Re‐evaluation of oxidised starch (E 1404) monostarch phosphate (E 1410) distarch phosphate (E 1412) phosphated distarch phosphate (E 1413) acetylated distarch phosphate (E 1414) acetylated starch (E 1420) acetylated distarch adipate (E 1422) hydroxypropyl starch (E 1440) hydroxypropyl distarch phosphate (E 1442) starch sodium octenyl succinate (E 1450) acetylated oxidised starch (E 1451) and starch aluminium octenyl succinate (E 1452) as food additives

机译：重新评估氧化淀粉（E 1404）磷酸单淀粉（E 1410）磷酸二淀粉（E 1412）磷酸二淀粉磷酸（E 1413）乙酰化磷酸二淀粉（E 1414）乙酰化淀粉（E 1420）乙酰化淀粉己二酸酯（E1421422）羟丙基淀粉（E 1440）羟丙基二淀粉磷酸酯（E 1442）淀粉辛烯基琥珀酸钠（EE1450）乙酰化氧化淀粉（EE1451）和淀粉辛烯基琥珀酸铝（EE1452）作为食品添加剂

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Following a request from the European Commission, the Panel on Food Additives and Nutrient sources added to Food ( ) was asked to deliver a scientific opinion on the re‐evaluation of 12 modified starches (E 1404, E 1410, E 1412, E 1413, E 1414, E 1420, E 1422, E 1440, E 1442, E 1450, E 1451 and E 1452) authorised as food additives in the in accordance with Regulation ( ) No 1333/2008 and previously evaluated by and the . Both committees allocated an acceptable daily intake ( ) ‘not specified’. In humans, modified starches are not absorbed intact but significantly hydrolysed by intestinal enzymes and then fermented by the intestinal microbiota. Using the read‐across approach, the Panel considered that adequate data on short‐ and long‐term toxicity and carcinogenicity, and reproductive toxicity are available. Based on analyses, modified starches are considered not to be of genotoxic concern. No treatment‐related effects relevant for human risk assessment were observed in rats fed very high levels of modified starches (up to 31,000 mg/kg body weight (bw) per day). Modified starches (e.g. E 1450) were well tolerated in humans up to a single dose of 25,000 mg/person. Following the conceptual framework for the risk assessment of certain food additives, the Panel concluded that there is no safety concern for the use of modified starches as food additives at the reported uses and use levels for the general population and that there is no need for a numerical . The combined exposure to E 1404–E 1451 at the 95th percentile of the refined (brand‐loyal) exposure assessment scenario for the general population was up to 3,053 mg/kg bw per day. Exposure to E 1452 for food supplement consumers only at the 95th percentile was up to 22.1 mg/kg bw per day.
机译：应欧盟委员会的要求，食品（食品添加剂和营养素）专家小组被要求就12种改性淀粉的重新评估发表科学意见（E 1404，E 1410，E 1412，E 1413， E（1414，E 1420，E 1422，E 1440，E 1442，E 1450，E 1451和E 1452）已根据（）No（1333/2008）法规获准作为食品添加剂，并事先由和评估。两个委员会均将可接受的每日摄入量（）分配为“未指定”。在人类中，改性淀粉不会被完整吸收，而是会被肠道酶显着水解，然后被肠道菌群发酵。小组采用跨学科方法，认为可获得关于短期和长期毒性和致癌性以及生殖毒性的足够数据。根据分析，改性淀粉被认为与基因毒性无关。在饲喂非常高水平的变性淀粉（每天高达31,000 mg / kg体重（bw））的大鼠中，未观察到与人类风险评估相关的与治疗相关的作用。人体对变性淀粉（例如E 1450）的耐受性最高，单剂量达25,000 mg /人。根据对某些食品添加剂进行风险评估的概念框架，小组得出结论认为，按照报告的用途和普通大众水平使用改性淀粉作为食品添加剂不会引起安全隐患，并且不需要数值的。在一般人群的精炼（品牌忠诚）暴露评估方案的第95个百分位数处，E 1404–E 1451的总暴露量高达每天3,053 mg / kg bw。仅在第95个百分位数处，食品补充剂消费者暴露于E1452的水平每天高达22.1 mg / kg bw。

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