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首页> 美国卫生研究院文献>EFSA Journal >Safety and efficacy of Hemicell®HT (endo‐14‐β‐d‐mannanase) as a feed additive for chickens for fattening chickens reared for laying turkey for fattening turkeys reared for breeding weaned piglets pigs for fattening and minor poultry and porcine species
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Safety and efficacy of Hemicell®HT (endo‐14‐β‐d‐mannanase) as a feed additive for chickens for fattening chickens reared for laying turkey for fattening turkeys reared for breeding weaned piglets pigs for fattening and minor poultry and porcine species

机译：Hemicell®的安全性和有效性HT（endo-14-β-d-甘露聚糖酶）作增肥鸡饲料饲养鸡育肥火鸡育肥火鸡断奶仔猪育肥猪以及小家禽和猪的饲料添加剂

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Hemicell is a feed additive with endo‐1,4‐β‐ ‐mannanase as the main enzymatic activity that is available in solid ( ) and liquid ( ‐L) forms. The production strain of the enzyme is a genetically modified strain of . The recipient strain is considered to be safe, the sequences introduced to obtain the production strain do not raise safety concerns. The absence of the production strain and of recombinant in the product was not proven. The additive is safe for the target species at the corresponding recommended doses. The use of Hemicell as a feed additive does not give rise to concerns for consumers. Hemicell and Hemicell ‐L are not irritant to the skin and eyes; Hemicell is a skin sensitiser. No specific data were provided on the effects on the respiratory system; however, considering the nature of the active substance, the additive is considered a potential respiratory sensitiser. The active substance of the additive is a protein, and as such, it will be degraded/inactivated during passage through the digestive tract of the animals or in the environment. However, uncertainty remains on the absence of the production strain and of recombinant in the product, consequently, the Panel could not conclude on the environmental safety of the product with regard to the genetically modified production strain. The additive has the potential to be efficacious in chickens for fattening at 32,000 U/kg feed and at 48,000 U/kg feed in turkeys for fattening and weaned piglets. These conclusions were extended to chickens reared for laying and turkeys reared for breeding and extrapolated to minor poultry species for fattening or reared for laying/breeding. The Panel could not conclude on the efficacy of the product in pigs for fattening or in minor porcine species.
机译：海米塞尔 是一种以内消旋1,4-β-甘露聚糖酶为主要酶活性的饲料添加剂，有固体（）和液体（-L）形式可用。该酶的生产菌株是大豆的转基因菌株。受体菌株被认为是安全的，为获得生产菌株而引入的序列不会引起安全隐患。没有证明在产品中不存在生产菌株和重组体。对于相应的推荐剂量，该添加剂对目标物种而言是安全的。 Hemicell的使用 作为饲料添加剂不会引起消费者的关注。海米塞尔 和半米 ‐L对皮肤和眼睛无刺激;海米塞尔 是一种皮肤敏化剂。没有提供对呼吸系统影响的具体数据;然而，考虑到活性物质的性质，该添加剂被认为是潜在的呼吸致敏剂。添加剂的活性物质是蛋白质，因此，在通过动物的消化道或环境中时，它将被降解/失活。但是，仍然不确定是否存在生产菌株和产品中的重组体，因此，专家小组无法就转基因生产菌株的产品环境安全性得出结论。该添加剂具有在鸡中以32,000 U / kg饲料增肥的功效，在火鸡中以48,000 U / kg饲料增肥和断奶仔猪的功效。这些结论适用于饲养的鸡和火鸡的饲养，也可以推广到次要的家禽品种中进行育肥或饲养/繁殖。专家小组无法就该产品在猪中育肥或在小型猪中的功效得出结论。

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