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首页> 美国卫生研究院文献>Pharmaceuticals >Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized Double-Blind Placebo-Controlled Study
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Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized Double-Blind Placebo-Controlled Study

机译：Raceaea racemosa L.与Rhodiola rosea L.联合使用可更有效地缓解更年期症状：一项随机双盲安慰剂对照的研究

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摘要

: The aim of this study was to assess the efficacy and safety of a new herbal preparation (Menopause Relief EP ), the hybrid combination of L. (black cohosh, BC) and L. (RR) root extracts, compared with the most effective dose of BC extract in women with menopausal complaints. A total of 220 women were randomly assigned to receive two capsules either BC (6.5 mg), BC500 (500 mg), Menopause Relief EP (206,5), or placebo once per day for 12 weeks. The efficacy endpoints were relief of menopausal symptoms, measured using the Kupperman Menopausal Index (KMI), Menopause Relief Score (MRS), and menopause Utian Quality of Life (UQOL) index. The menopause symptom relief effects of RR-BC were significantly superior in all tests to the effects of BC and placebo after their repeated administration for 6 and 12 weeks. There was no statistically significant difference between the effects of BC and BC500 over time. RR-BC significantly improved the QOL index in patients, compared to BC, BC500, and placebo, mainly due to the beneficial effects on the emotional and health domains. BC is more effective in combination with RR in relief of menopausal symptoms, particularly psychological symptoms.
机译：：本研究的目的是评估一种新草药制剂（更年期缓解剂EP）的功效和安全性，该草药制剂是最有效的L.（黑升麻，BC）和L.（RR）根提取物的混合组合。绝经期妇女的BC提取物的剂量。总共有220名妇女被随机分配接受BC（6.5 mg），BC500（500 mg），更年期缓解EP（206,5）或安慰剂两个胶囊，每天一次，共12周。疗效终点是更年期症状的缓解，使用库珀曼更年期指数（KMI），更年期缓解评分（MRS）和更年期生活质量（UQOL）指数进行测量。在所有试验中，RR-BC的更年期症状缓解效果在重复给药6周和12周后均显着优于BC和安慰剂。随着时间的推移，BC和BC500的影响之间没有统计学上的显着差异。与BC，BC500和安慰剂相比，RR-BC显着改善了患者的QOL指数，这主要是由于对情感和健康领域的有益作用。 BC与RR联合使用可更有效地缓解更年期症状，尤其是心理症状。

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