首页> 美国卫生研究院文献>Translational Animal Science >Comparison of the effect of tildipirosin administered alone or in combination with transdermal flunixin on the performance health activity and well-being of transported feedlot calves on arrival at the feedlot
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Comparison of the effect of tildipirosin administered alone or in combination with transdermal flunixin on the performance health activity and well-being of transported feedlot calves on arrival at the feedlot

机译:单独或与透皮氟尼辛合用的替地吡辛对到达育肥场的运输育肥牛犊的性能健康活性和健康的影响比较

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摘要

Long distance transportation can be a significant source of stress to cattle and is associated with increased risk of bovine respiratory disease (BRD). The administration of a nonsteroidal anti-inflammatory drug (NSAID) has been shown to reduce stress following long distance transport. The objective of this study was to compare performance, health, accelerometer activity, and well-being between calves receiving either tildipirosin (Zuprevo 18%; Merck Animal Health, Madison, NJ) alone or in combination with transdermal flunixin (BANAMINE Transdermal Pour-on Solution; Merck Animal Health, Madison, NJ) on arrival at the feedlot. Three hundred eighty-four polled, Continental × English, and English crossbred bulls (  = 199) and steers (  = 185) were enrolled into one of two treatments: 1) tildipirosin administered in the neck as a single dose of 4 mg/kg only (PLBO) 2) tildipirosin in combination with transdermal flunixin applied to the dorsal midline at a dose of 3.3 mg/kg (FTD). Outcomes measured were average daily gain (ADG), dry mater intake (DMI), gain to feed, morbidity, mortality, accelerometer activity data, and a daily visual analog scale (VAS) assessment of well-being. Body weight (BW) was determined by weighing individual animals; ADG was calculated as initial BW—final BW / total days on feed; DMI was calculated as daily pen feed allocation—feed remaining at next feeding / number of calves in the pen; and gain to feed was calculated as pen level ADG / pen level DMI. The VAS used was a 100 mm line anchored at each end by descriptors of “no pain” or “severe pain”. Statistical analysis was performed using JMP 13 computer software using pen as the experimental unit, lot number as a random variable, and treatment as a fixed variable. There was no treatment effect on DMI (  = 0.51). During the first 14 d on feed, FTD calves had a lower ADG of 0.90 kg/d compared with 1.33 kg/d in the PLBO group (  = 0.05). There were no differences observed in morbidity and mortality between groups (  = 0.29). There were no treatment differences from activity data (  = 0.19). The VAS assessment showed a significant time × treatment interaction (  P
机译:长途运输可能是牛的重要压力来源,并且与牛呼吸道疾病(BRD)的风险增加有关。非甾体抗炎药(NSAID)的使用已显示可减少长途运输后的压力。这项研究的目的是比较单独接受替地吡辛(Zuprevo 18%;默克动物保健,麦迪逊,新泽西州)或与经皮氟尼辛(BANAMINE透皮浇​​注法)联合应用的小牛之间的性能,健康,加速度计活动和健康状况。解决方案;到达饲养场后,默克动物健康公司,新泽西州麦迪逊市)。接受三百四十四次民意测验,大陆性××英语和英国杂交公牛(= 199)和and牛(= 185)的两种治疗方法之一:1)头孢吡松仅以4 mg / kg的单剂量给药于颈部(PLBO)2)替地吡辛与经皮氟尼辛的组合以3.3 mg / kg(FTD)的剂量应用于背部中线。测得的结果是平均日增重(ADG),干母乳采食量(DMI),进食增重,发病率,死亡率,加速计活动数据以及每日视觉模拟量表(VAS)的幸福感评估。体重(BW)通过称重单个动物来确定; ADG计算为初始体重-最终体重/饲料总天数; DMI的计算方法为每日饲喂饲料分配-下次饲喂时剩余的饲料/围栏中的犊牛数量;进料增益计算为笔水平ADG /笔水平DMI。所使用的VAS是一条100毫米的线,其两端分别用“无痛”或“重度疼痛”来形容。使用JMP 13计算机软件进行统计分析,使用笔作为实验单位,批号作为随机变量,处理作为固定变量。对DMI没有治疗作用(= 0.51)。在进食的前14天中,FTD犊牛的ADG较低,为0.90 kg / d,而PLBO组为1.33 kg / d(=)0.05)。两组之间的发病率和死亡率无差异((= 0.29)。活动数据与治疗无差异(= 0.19)。 VAS评估显示出显着的时间×××治疗相互作用((P

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