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首页> 美国卫生研究院文献>Journal of Functional Biomaterials >Substituted Nano-Hydroxyapatite Toothpastes Reduce Biofilm Formation on Enamel and Resin-Based Composite Surfaces
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Substituted Nano-Hydroxyapatite Toothpastes Reduce Biofilm Formation on Enamel and Resin-Based Composite Surfaces

机译：取代的纳米羟基磷灰石牙膏可减少牙釉质和树脂基复合表面上生物膜的形成

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: Toothpastes containing nano-hydroxyapatite (n-HAp) substituted with metal ions provide calcium and phosphate ions to dental hard tissues, reducing demineralization, and promoting remineralization. Few data are available about the effect of these bioactive compounds on oral microbiota. : This in vitro study evaluated the influence of two commercially-available substituted n-HAp-based toothpastes (α: Zn-carbonate substituted n-HAp; β: F, Mg, Sr-carbonate substituted n-HAp) on early colonization (EC, 12 h) and biofilm formation (BF, 24 h) by oral microbiota. Controls were brushed with distilled water. Artificial oral microcosm and biofilms were developed using human enamel and a resin-based composite (RBC) as adherence surfaces. Two test setups, a shaking multiwell plate and a modified drip-flow reactor (MDFR), were used to simulate clinical conditions during the night (low salivary flow and clearance) and daytime, respectively. Energy-dispersive X-ray spectrometry (EDS) was used to evaluate specimens’ surfaces after toothpaste treatment. Fluoride release from β toothpaste was evaluated. Viable adherent biomass was quantified by MTT assay, and biofilms’ morphology was highlighted using confocal microscopy. : EDS showed the presence of remnants from the tested toothpastes on both adherence surfaces. β toothpaste showed significantly lower EC and BF compared to control using the artificial oral microcosm model, while α toothpaste showed lower EC and BF compared to control, but higher EC and BF compared to β toothpaste. The effect shown by β toothpaste was, to a minimal extent, due to fluoride release. Interestingly, this result was seen on both adherence surfaces, meaning that the tested toothpastes significantly influenced EC and BF even on RBC surfaces. Furthermore, the effect of toothpaste treatments was higher after 12 h than 24 h, suggesting that toothbrushing twice a day is more effective than brushing once. : The efficacy of these treatments in reducing microbial colonization of RBC surfaces may represent a promising possibility in the prevention of secondary caries.
机译：：含有被金属离子取代的纳米羟基磷灰石（n-HAp）的牙膏可为牙齿硬组织提供钙离子和磷酸根离子，减少脱矿质并促进再矿化。关于这些生物活性化合物对口腔微生物的影响的数据很少。 ：这项体外研究评估了两种市售的基于取代n-HAp的牙膏（α：碳酸锌取代的n-HAp;β：F，Mg，Sr碳酸酯取代的n-HAp）对早期定殖的影响（EC ，12 h）和口腔微生物群形成生物膜（BF，24 h）。对照用蒸馏水刷洗。使用人类牙釉质和树脂基复合材料（RBC）作为粘附表面开发了人工口腔缩微和生物膜。两种测试装置分别是振动多孔板和改进的滴流反应器（MDFR），用于模拟夜间（唾液流量和清除率低）和白天的临床状况。能量色散X射线光谱（EDS）用于评估牙膏处理后标本的表面。评估了β牙膏中氟化物的释放。通过MTT测定法定量存活的粘附生物量，并使用共聚焦显微镜突出显示生物膜的形态。 ：EDS显示在两个粘附表面上都存在来自测试牙膏的残留物。与使用人工口腔缩影模型的对照组相比，β牙膏的EC和BF显着降低，而α牙膏的EC和BF则显着低于对照组，而EC和BF则比β牙膏高。 β牙膏显示的作用在最小程度上是由于氟化物的释放。有趣的是，在两个粘附表面上都可以看到该结果，这意味着即使在RBC表面上，被测试的牙膏也显着影响EC和BF。此外，在12小时之后牙膏治疗的效果要比24小时更高，这表明每天两次刷牙比一次刷牙更有效。 ：这些治疗方法在减少红细胞表面微生物定殖方面的功效可能代表了预防继发性龋齿的一种有前途的可能性。

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