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首页> 美国卫生研究院文献>Food Science Nutrition >Laxative and antioxidant effects of ramie (Boehmeria nivea L.) leaf extract in experimental constipated rats
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Laxative and antioxidant effects of ramie (Boehmeria nivea L.) leaf extract in experimental constipated rats

机译：of麻叶片提取物对实验性便秘大鼠的通便和抗氧化作用

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Ramie leaf ( L.) is rich in cellulose, polyphenol compounds, vitamin C, and minerals. The leaves of this plant, which are used for medicinal purposes, have long been reported to have anti‐inflammatory, antioxidant, anticolitis, and antidiabetic effects. We investigated the protective effects of ramie leaf ethanol extract (RLE) against loperamide‐induced constipation and oxidative stress in rats. Male Sprague‐Dawley rats were administered 200 or 400 mg/kg body weight of RLE (RLEL and RLEH groups) by gavage, while normal (NOR) and control (CON) rats received saline. Loperamide (4.0 mg/kg, twice per day) was injected subcutaneously to induce constipation in RLEL, RLEH, and CON groups. Total fecal number, wet weight, and water content decreased, while the total number of loperamide‐induced fecal pellets in the distal colon increased with administration of RLE in a dose‐dependent manner. Gastrointestinal transit time was more greatly reduced in RLE‐treated groups than in the CON group. Serum total cholesterol (TC) level, as well as alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activity, was significantly lower in both RLEL and RLEH groups compared with the CON group. Intestinal mucosa malondialdehyde (MDA) and hydrogen peroxide (H O ) production decreased significantly in a dose‐dependent manner in the RLE‐treated groups. Loperamide decreased the antioxidant enzyme activity, including that of superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px), while RLE administration increased the antioxidant activity. These results suggest that RLE exerts potent laxative and antioxidant effects in model rats with loperamide‐induced constipation.
机译：ie麻叶（L.）富含纤维素，多酚化合物，维生素C和矿物质。长期以来，据报道该植物的叶子用于药用，具有抗炎，抗氧化，抗结肠炎和抗糖尿病作用。我们研究了of麻叶乙醇提取物（RLE）对洛哌丁胺引起的便秘和大鼠氧化应激的保护作用。雄性Sprague-Dawley大鼠通过管饲法给予200或400 mg / kg体重的RLE（RLEL和RLEH组），而正常（NOR）和对照（CON）大鼠则接受生理盐水。皮下注射洛哌丁胺（4.0 mg / kg，每天两次）以诱发RLEL，RLEH和CON组的便秘。随着RLE剂量依赖性给药，粪便总数，湿重和水分减少，而洛哌丁胺诱导的远端结肠粪便颗粒总数增加。与CON组相比，RLE治疗组的胃肠道通过时间大大减少。与CON组相比，RLEL和RLEH组的血清总胆固醇（TC）水平以及丙氨酸氨基转移酶（ALT）和碱性磷酸酶（ALP）活性均显着降低。在RLE治疗组中，肠粘膜丙二醛（MDA）和过氧化氢（H O）的产生呈剂量依赖性显着降低。洛哌丁胺会降低抗氧化酶活性，包括超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px），而RLE给药会增加抗氧化活性。这些结果表明，RLE在洛哌丁胺诱发的便秘模型大鼠中发挥强效的通便和抗氧化作用。

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