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首页> 美国卫生研究院文献>Foods >Antioxidant Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates
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Antioxidant Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates

机译：米糠蛋白水解物的抗氧化血管紧张素转换酶抑制特性和降血压作用

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This research aimed to investigate the biological properties of different hydrolysates derived from industrial and laboratory defatted rice bran proteins. Industrial and laboratory defatted rice bran protein concentrates were hydrolyzed with alcalase or flavorzyme. The degree of hydrolysis (DH), oxygen radical absorbance capacity (ORAC), reducing power, total phenolic compounds (TPC), and angiotensin-converting enzyme (ACE) inhibitory activity, were determined in the hydrolysates and the molecular fractions lower than 3 kDa. Systolic blood pressure (SBP) was measured using the tail-cuff method before and after oral administration of 80 mg/kg of different rice bran protein hydrolysate (RBPH) fractions lower than 3 kDa in male spontaneously hypertensive rats (SHR) and normotensive Wistar–Kyoto (WKY) rats. The highest values of in vitro antioxidant activity and TPC were observed in RBPH with alcalase defatted by industry (RBPH2A), and, in all cases, these bioactivities were higher in the molecular fractions lower than 3 kDa. Once again, fractions lower than 3 kDa obtained with alcalase showed a potent ACE inhibitory activity (RBPH1A<3 and RBPH2A<3). The administration of RBPH1A<3 caused a significant decrease in the SBP in SHR, where the maximum decrease was reached at 8 h after administration. SBP in WKY rats was not modified after the administration of RBPH1A<3. These results suggest that the rice bran protein hydrolysates obtained from industry after treatment with alcalase could be an interesting source of bioactive peptides, with potential action on hypertension and other related pathologies.
机译：这项研究旨在研究工业和实验室脱脂米糠蛋白衍生的不同水解产物的生物学特性。工业和实验室脱脂的米糠蛋白浓缩物用碱性蛋白酶或风味酶水解。确定了水解产物中的水解度（DH），氧自由基吸收能力（ORAC），还原能力，总酚化合物（TPC）和血管紧张素转化酶（ACE）抑制活性，并且分子级分低于3 kDa 。在雄性自发性高血压大鼠（SHR）和血压正常的Wistar –京都（WKY）老鼠。在工业界脱脂的碱性蛋白酶（RBPH2A）中，在RBPH中观察到了最高的体外抗氧化活性和TPC值，并且在所有情况下，低于3 kDa的分子级分中这些生物活性较高。再次，用alcalase获得的低于3kDa的级分显示​​出有效的ACE抑制活性（RBPH1A ＜3和RBPH2A ＜3）。 RBPH1A <3的使用引起SHR的SBP显着下降，在给药后8小时达到最大下降。 RBPH1A <3后，WKY大鼠的SBP没有改变。这些结果表明，用alcalase处理后从工业获得的米糠蛋白水解物可能是有趣的生物活性肽来源，具有对高血压和其他相关病理学的潜在作用。

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