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首页> 美国卫生研究院文献>Cancers >Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population
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Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population

机译：在韩国筛查人群中不同乳腺癌密度类别的危险因素对乳腺癌的异质性影响

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We evaluated the heterogeneity of the effect of known risk factors on breast cancer development based on breast density by using the Breast Imaging-Reporting and Data System (BI-RADS). In total, 4,898,880 women, aged 40–74 years, who participated in the national breast cancer screening program in 2009–2010 were followed up to December 2018. Increased age showed a heterogeneous association with breast cancer (1-year hazard ratio (HR) = 0.92, 1.00 (reference), 1.03, and 1.03 in women with BI-RADS density category 1, 2, 3, and 4, respectively; P-heterogeneity < 0.001). More advanced age at menopause increased breast cancer risk in all BI-RADS categories. This was more prominent in women with BI-RADS density category 1 but less prominent in women in other BI-RADS categories (P-heterogeneity = 0.009). In postmenopausal women, a family history of breast cancer, body mass index ≥ 25 kg/m , and smoking showed a heterogeneous association with breast cancer across all BI-RADS categories. Other risk factors including age at menarche, menopause, hormone replacement therapy after menopause, oral contraceptive use, and alcohol consumption did not show a heterogeneous association with breast cancer across the BI-RADS categories. Several known risk factors of breast cancer had a heterogeneous effect on breast cancer development across breast density categories, especially in postmenopausal women.
机译：我们使用乳房成像报告和数据系统（BI-RADS），根据乳房密度评估了已知危险因素对乳腺癌发展的影响的异质性。截止至2018年12月，共有4,898,880名40-74岁的妇女参加了2009-2010年的国家乳腺癌筛查计划。随着年龄的增长，其与乳腺癌的异质性关联（1年危险比（HR）分别将BI-RADS密度分类为1、2、3和4的女性分别设为0.92、1.00（参考），1.03和1.03; P-异质性<0.001）。在所有BI-RADS类别中，更年期的高龄会增加患乳腺癌的风险。这在BI-RADS密度类别为1的女性中更为显着，但在其他BI-RADS类别的女性中则较不显着（P-异质性= 0.009）。在绝经后妇女中，乳腺癌的家族病史，体重指数≥25 kg / m 3和吸烟在所有BI-RADS类别中均显示出与乳腺癌的异质关联。在BI-RADS类别中，其他风险因素包括初潮年龄，更年期，绝经后激素替代疗法，口服避孕药和饮酒并未显示出与乳腺癌的异质关联。几种已知的乳腺癌危险因素在整个乳腺密度类别中，特别是在绝经后妇女中，对乳腺癌的发展具有不同的影响。

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