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首页> 外文会议>Digital mammography >Volumetric Breast Density and Breast Cancer Risk Factors in a Screening Population
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Volumetric Breast Density and Breast Cancer Risk Factors in a Screening Population

机译：筛查人群的乳房密度和乳腺癌危险因素

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摘要

Breast density is positively linked to the risk of developing breast cancer. Furthermore, the addition of breast density as an input to breast cancer risk prediction models has been shown to improve their predictive power. Such models are used in the management of women at high risk but could potentially be used to determine screening strategy. A stepwedge-based technique has been used to measure volumetric density from the mammograms of 1,289 women in the UK screening programme who additionally completed a questionnaire on risk-related factors. The sample had a mean age of 60.1 (range 48.0 - 78.0), a mean breast thickness of 59mm (range 21 - 102mm) and a mean volumetric breast density of 11% (range 0.5 - 58%). Using Pearson's correlation coefficient, breast density was found to be significantly correlated with weight (r = -0.45), body mass index (r = -0.48), age (r = -0.13) and breast thickness (r =-0.65) at the p = 0.01 level. Absolute glandular volume was also found to be significantly correlated with these parameters although the extent of correlation was weaker.
机译：乳房密度与患乳腺癌的风险呈正相关。此外，已证明增加乳房密度作为乳腺癌风险预测模型的输入可提高其预测能力。此类模型用于管理高危妇女，但有可能用于确定筛查策略。在英国筛查计划中，基于阶梯楔形的技术已被用于从1289名妇女的乳房X线照片中测量体积密度，这些妇女还完成了与风险相关因素的问卷调查。样本的平均年龄为60.1（范围为48.0-78.0），平均乳房厚度为59mm（范围为21-102mm），平均体积乳房密度为11％（范围为0.5-58％）。使用皮尔逊相关系数，发现乳房密度与体重（r = -0.45），体重指数（r = -0.48），年龄（r = -0.13）和乳房厚度（r = -0.65）显着相关。 p = 0.01水平。尽管相关程度较弱，但也发现绝对腺体体积与这些参数显着相关。

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  • 来源
    《Digital mammography》|2010年|p.386-393|共8页
  • 会议地点 Girona(ES);Girona(ES)
  • 作者

    Jennifer Diffey; Joanna Morrison; Michael Berks; Joanne Greene; Julie Morris; Anthony Maxwell; Caroline Boggis; Alan Hufton; Susan Astley;

  • 作者单位

    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT;

    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT;

    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT;

    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT;

    Department of Medical Statistics, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Wythenshawe, Manchester, United Kingdom, M23 9LT;

    Bolton, Bury and Rochdale Breast Screening Service, Royal Bolton Hospital, Bolton, Lancashire, BL4 OJR;

    The Nightingale Centre and Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Wythenshawe, Manchester, United Kingdom, M23 9LT;

    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT;

    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

    breast density; volumetric technique; risk factors;

    机译：乳房密度体积技术风险因素;

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