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首页> 美国卫生研究院文献>Human Brain Mapping >Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use
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Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use

机译：Nucleus Accumbens与中央行政网络之间的动态功能连接涉及慢性大麻使用

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The neural mechanisms of drug cue‐reactivity regarding the temporal fluctuations of functional connectivity, namely the dynamic connectivity, are sparsely studied. Quantifying the task‐modulated variability in dynamic functional connectivity at cue exposure can aid the understanding. We analyzed changes in dynamic connectivity in 54 adult cannabis users and 90 controls during a cannabis cue exposure task. The variability was measured as standard deviation in the (a) connectivity weights of the default mode, the central executive, and the salience networks and two reward loci (amygdalae and nuclei accumbens); and (b) topological indexes of the whole brain (global efficiency, modularity and network resilience). These were compared for the main effects of task conditions and the group (users vs. controls), and correlated with pre‐ and during‐scan subjective craving. The variability of connectivity weights between the central executive network and nuclei accumbens was increased in users throughout the cue exposure task, and, was positively correlated with during‐scan craving for cannabis. The variability of modularity was not different by groups, but positively correlated with prescan craving. The variability of dynamic connectivity during cannabis cue exposure task between the central executive network and the nuclei accumbens, and, the level of modularity, seem to relate to the neural underpinning of cannabis use and the subjective craving.
机译：关于功能性连通性的时间波动，即动态连接的药物管道反应性的神经机制稀疏地研究。量化CUE曝光时动态功能连接中的任务调制变异可以帮助了解。我们在大麻提示曝光任务中分析了54个成年大麻用户的动态连接的变化和90个控件。在默认模式，中央行政和突出性网络和两个奖励基因座（Amygdalae和核戒烟）的（a）的连接权中，测量变异性作为标准偏差。 （b）全大脑的拓扑指标（全球效率，模块化和网络弹性）。将这些与任务条件和组（用户与控制）的主要效果进行比较，并与扫描前和扫描期主观渴望相关。在整个提示曝光任务的用户中，中央行政网络和核常压之间的连接权重的变化增加，并且与大麻的扫描期间，与扫描期间呈正相关。模块化的可变性不属于群体，但与预见的渴望呈正相关。在中央行政网络和核心子系统之间的大麻提示曝光任务期间动态连接的可变性，以及模块化水平，似乎与大麻使用的神经内限和主观渴望有关。

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