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首页> 外文期刊>Addiction >Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood
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Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood

机译：核心uncumbens在20岁时的功能连接与青少年大麻使用的轨迹有关，并预测年轻成年期的心理社会功能

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Abstract Aims (1) To identify trajectories of cannabis use across adolescence, (2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc) and (3) to assess whether patterns of functional connectivity related to cannabis use are associated with psychosocial functioning 2 years later. Design The Pitt Mother and Child Project (PMCP) is a prospective, longitudinal study of male youth at high risk for psychopathology based on family income and gender. Setting Participants were recruited between age 6 and 17 months from the Women, Infants and Children Nutritional Supplement program (WIC) in the Pittsburgh, Pennsylvania area. Participants A total of 158 PMCP young men contributed functional magnetic resonance imaging (fMRI) and substance use data at age 20?years. Measurements Latent class growth analysis was used to determine trajectories of cannabis use frequency from age 14 to 19?years. Psychophysiological interaction (PPI) analysis was used to measure functional connectivity between the NAcc and prefrontal cortex (PFC). Adolescent cannabis use trajectory, recent frequency of use and age of initiation were considered as developmental factors. We also tested whether functional connectivity was associated with depressive symptoms, anhedonia and educational attainment at age 22. Findings We identified three distinct trajectories of adolescent cannabis use, characterized by stable high, escalating or stable low use. The cannabis use trajectory group had a significant effect on NAcc functional connectivity to the medial PFC ( F ?=?11.32, Z ?=?4.04, P family‐wise error‐corrected (FWE‐corr) ?=?0.000). The escalating trajectory group displayed a pattern of negative NAcc‐mPFC connectivity that was linked to higher levels of depressive symptoms ( r ?=?–0.17, P ??.05), anhedonia ( r ?=?–0.19, P ??.05) and lower educational attainment ( t ?=?–2.77, P ??.01) at age 22. Conclusions Pattern of cannabis use frequency across adolescence in US youth could have consequences for mood symptoms and educational attainment in early adulthood via altered function in neural reward circuitry.
机译：摘要目标（1）识别跨青春期使用大麻的轨迹，（2）测量大麻使用特征对核核心（NACC）的功能连通性的影响（3），以评估与大麻使用相关的功能连接模式2年后与心理社会功能相关联。设计PITT母婴项目（PMCP）是基于家庭收入和性别的心理病理学的高风险前瞻性，纵向研究。在宾夕法尼亚州匹兹堡的妇女，婴儿和儿童营养补充计划（WIC）之间招聘参与者在彼得堡，宾夕法尼亚州匹兹堡。参与者共有158个PMCP青年男子贡献功能磁共振成像（FMRI）和20岁时使用数据？年龄。测量潜在阶级增长分析用于确定大麻使用频率从14岁到19岁的轨迹？年。使用精神生理相互作用（PPI）分析用于测量NACC和前额叶皮质（PFC）之间的功能性连通性。青少年大麻使用轨迹，最近的使用频率和启动年龄被认为是发育因素。我们还测试了功能性连通性是否与年龄22岁的抑郁症状有关。调查结果我们确定了三种不同的青少年使用轨迹，其特征在于稳定的高，升级或稳定的低利用率。大麻使用轨迹组对内侧PFC的NACC功能连接有显着影响（F？= 11.32，Z？= 4.04，P家族 - 明智的错误纠正（FWE-Corr）？=？0.000）。升级的轨迹组显示了负NACC-MPFC连接的模式，与较高水平的抑郁症状（R？=？ - 0.17，p≤05），anhedonia（r？=？ - 0.19，p？ ＆ 05）和较低的教育程度（t？=？ - 2.77，p？＆Δ01）。结论美国青年青春期的大麻使用频率的模式可能对情绪症状和教育程度产生后果。通过神经奖励电路的改变功能早期过去。

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