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首页> 美国卫生研究院文献>Pharmaceutics >Development of a Nonwoven Hemostatic Dressing Based on Unbleached Cotton: A De Novo Design Approach
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Development of a Nonwoven Hemostatic Dressing Based on Unbleached Cotton: A De Novo Design Approach

机译：基于未漂白棉花的非织造止血敷料的开发：DE Novo设计方法

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Minimally processed greige (unbleached) cotton fibers demonstrate enhanced clotting relative to highly processed (USP) type 7 bleached cotton gauze. This effect is thought to be due to the material surface polarity. We hypothesized that a textile could be constructed, conserving the hemostasis-accelerating properties of greige cotton, while maintaining structural integrity and improving absorbance. Spun bond nonwovens of varying surface polarity were designed and prepared based on ratios of greige cotton/bleached cotton/polypropylene fibers. A thromboelastographic analysis was performed on fibrous samples in citrated blood to evaluate the rate of fibrin and clot formation. Lee White clotting times were obtained to assess the material’s clotting activity in platelet fresh blood. An electrokinetic analysis of samples was performed to analyze for material surface polarity. Hemostatic properties varied with composition ratios, fiber density, and fabric fenestration. The determinations of the surface polarity of cotton fabrics with electrokinetic analysis uncovered a range of surface polarities implicated in fabric-initiated clotting; a three-point design approach was employed with the combined use of thromboelastography, thrombin velocity index, Lee White clotting, and absorption capacity determinations applied to fabric structure versus function analysis. The resulting analysis demonstrates that greige cotton may be utilized, along with hydrophilic and hydrophobic fibers, to improve the initiation of fibrin formation and a decrease in clotting time in hemostatic dressings suitable to be commercially developed. Hydroentanglement is an efficient and effective process for imparting structural integrity to cotton-based textiles, while conserving hemostatic function.
机译：微量加工的Greige（未漂白）棉纤维表现出相对于高处加工（USP）7型漂白棉纱的增强凝血。认为这种效果是由于材料表面极性。我们假设可以构建纺织品，保护灰色棉的止血性能，同时保持结构完整性和改善吸光度。基于Greige棉/漂白棉/聚丙烯纤维的比率设计和制备了不同表面极性的纺粘非织剂。对氧化血液中的纤维样品进行血栓间分析，评价纤维蛋白和凝块形成的速率。获得了李白凝视时间，以评估血小板新鲜血液中的材料凝血活性。进行样品的电动分析以分析材料表面极性。止血性能随组合物比率，纤维密度和织物变更而变化。棉织物具有电动分析的表面极性的测定揭示了一系列涉及织物引发凝血的表面极性;三点设计方法采用血栓球运动血栓球运动，凝血酶速度指数，李白凝固，施加到织物结构与功能分析的吸收能力测定。得到的分析表明，可以使用灰胶棉，以及亲水和疏水纤维，以改善纤维蛋白形成的起始，并且适合于商业开发的止血敷料的凝血时间的降低。水力抗静是一种有效且有效的方法，可赋予棉型纺织品的结构完整性，同时节省止血功能。

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