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首页> 外文期刊>Biomaterials >Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties.
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Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties.

机译：具有改善的止血和抗菌性能的基于壳聚糖的伤口敷料的开发。

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Hemorrhage remains a leading cause of early death after trauma, and infectious complications in combat wounds continue to challenge caregivers. Although chitosan dressings have been developed to address these problems, they are not always effective in controlling bleeding or killing bacteria. We aimed to refine the chitosan dressing by incorporating a procoagulant (polyphosphate) and an antimicrobial (silver). Chitosan containing different amounts and types of polyphosphate polymers was fabricated, and their hemostatic efficacies evaluated in vitro. The optimal chitosan-polyphosphate formulation (ChiPP) accelerated blood clotting (p = 0.011), increased platelet adhesion (p=0.002), generated thrombin faster (p = 0.002), and absorbed more blood than chitosan (p < 0.001). Silver-loaded ChiPP exhibited significantly greater bactericidal activity than ChiPP in vitro, achieving a complete kill of Pseudomonas aeruginosa and a > 99.99% kill of Staphylococcus aureus consistently. The silver dressing also significantly reduced mortality from 90% to 14.3% in a P. aeruginosa wound infection model in mice. Although the dressing exerted severe cytotoxicity against cultured fibroblasts, wound healing was not inhibited. This study demonstrated for the first time, the application of polyphosphate as a hemostatic adjuvant, and developed a new chitosan-based composite with potent hemostatic and antimicrobial properties.
机译：出血仍然是创伤后早期死亡的主要原因，战斗伤口的传染性并发​​症继续挑战护理人员。尽管已经开发出壳聚糖敷料来解决这些问题，但是它们并不总是有效地控制出血或杀死细菌。我们的目标是通过掺入促凝剂（聚磷酸盐）和抗菌剂（银）来精制壳聚糖敷料。制备了包含不同数量和类型的聚磷酸盐聚合物的壳聚糖，并在体外评估了它们的止血效果。最佳的壳聚糖-聚磷酸盐配方（ChiPP）可加速血液凝结（p = 0.011），增加血小板粘附性（p = 0.002），产生凝血酶的速度更快（p = 0.002）和比壳聚糖吸收更多的血液（p <0.001）。在体外，载银的ChiPP表现出比ChiPP明显更高的杀菌活性，始终完全杀死铜绿假单胞菌，并始终杀死大于99.99％的金黄色葡萄球菌。在小鼠的铜绿假单胞菌伤口感染模型中，银敷料还将死亡率从90％显着降低到14.3％。尽管敷料对培养的成纤维细胞产生了严重的细胞毒性，但是伤口的愈合并未受到抑制。这项研究首次证明了多磷酸盐作为止血佐剂的应用，并开发了一种新型的壳聚糖基复合材料，具有强大的止血和抗菌性能。

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