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首页> 美国卫生研究院文献>The Journal of Clinical Investigation >Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response.
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Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response.

机译：血管热休克蛋白表达响应压力。内分泌和自主调节这种年龄依赖性反应。

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摘要

Adaptation to stress requires coordinated interactions between the vascular and endocrine systems. Previously we demonstrated that restraint stress induces the expression of the major heat shock protein, HSP70, in the adrenal cortex of the rat. Here we demonstrate that restraint also induces expression of HSP70 in the vasculature. We further demonstrate that the adrenal and vascular responses are differentially regulated: the adrenal response is adrenocorticotropin dependent, whereas the vascular response is under adrenergic control. In addition, the adrenal response is restricted to members of the HSP70 gene family, whereas in vascular tissue the low molecular weight HSP, HSP27, is also induced by restraint. Further characterization of the vascular response revealed that HSP70 induction occurred in both the thoracic and abdominal aortas as well as in the vena cava. However, no HSP70 induction was apparent in the heart or in a wide variety of other tissues examined. In situ hybridization showed that the vascular expression was localized to the aortic smooth muscle cells with minimal expression in the endothelium. Induction of HSP70 mRNA in both the adrenal cortex and aorta was followed by an elevation in HSP70 protein. Maximum HSP70 protein levels were seen within 3-12 h after restraint, but declined thereafter. Stress induced HSP70 expression was dramatically reduced with age, which may explain, in part, the diminished tolerance to stress seen in elderly individuals.
机译：适应压力需要血管和内分泌系统之间协调的相互作用。先前我们证明了束缚应激可诱导大鼠肾上腺皮质主要热休克蛋白HSP70的表达。在这里，我们证明了约束还可以诱导脉管系统中HSP70的表达。我们进一步证明，肾上腺和血管反应是差异调节的：肾上腺反应是肾上腺皮质激素依赖性的，而血管反应在肾上腺素能控制下。此外，肾上腺反应仅限于HSP70基因家族的成员，而在血管组织中，低分子量的HSP HSP27也是通过约束诱导的。血管反应的进一步特征表明，HSP70诱导在胸主动脉和腹主动脉以及腔静脉中均发生。但是，在心脏或检查的多种其他组织中没有发现HSP70诱导。原位杂交显示血管表达局限于主动脉平滑肌细胞，在内皮中表达最少。在肾上腺皮质和主动脉中诱导HSP70 mRNA，然后升高HSP70蛋白。抑制后3-12小时内观察到最大HSP70蛋白水平，但此后下降。压力诱导的HSP70表达随着年龄的增长而显着降低，这可能部分解释了老年人对压力的耐受性下降。

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