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首页> 美国卫生研究院文献>International Journal of Molecular Medicine >Association between serum anti-ASXL2 antibody levels and acute ischemic stroke acute myocardial infarction diabetes mellitus chronic kidney disease and digestive organ cancer and their possible association with atherosclerosis and hypertension
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Association between serum anti-ASXL2 antibody levels and acute ischemic stroke acute myocardial infarction diabetes mellitus chronic kidney disease and digestive organ cancer and their possible association with atherosclerosis and hypertension

机译：血清抗ASX12抗体水平和急性缺血性卒中急性心肌梗死糖尿病慢性肾病和消化器官癌之间的关联及其与动脉粥样硬化和高血压的可能缔章

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The aim of the present study was to identify novel antibody markers for the early diagnosis of atherosclerosis in order to improve the prognosis of patients at risk for acute ischemic stroke (AIS) and acute myocardial infarction (AMI). A first screening involved the serological identification of antigens by recombinant cDNA expression cloning and identified additional sex combs-like 2 (ASXL2) as a target antigen recognized by serum IgG antibodies in the sera of patients with atherosclerosis. Antigens, including the recombinant glutathione S-transferasefused ASXL2 protein and its synthetic peptide were then prepared to examine serum antibody levels. Amplified luminescence proximity homoge-neous assay-linked immunosorbent assay, which incorporates glutathione-donor beads and anti-human-IgG-acceptor beads, revealed significantly higher serum antibody levels against the ASXL2 protein and its peptide in the patients with AIS, diabetes mellitus, AMI, chronic kidney disease, esophageal squamous cell carcinoma, or colorectal carcinoma compared with those in healthy donors. The ASXL2 antibody levels were well associated with hypertension complication, but not with sex, body mass index, habitual smoking, or alcohol intake. These results suggest that the serum ASXL2 antibody marker can discriminate between hypertension-induced atherosclerotic AIS and AMI, as well as a number of digestive organ cancers.

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