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首页> 美国卫生研究院文献>The Journal of Infectious Diseases >Photoinactivation of Neisseria gonorrhoeae: A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection
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Photoinactivation of Neisseria gonorrhoeae: A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection

机译：Neisseria Gonorrhoeae的光灭活：一种防范抗生素淋病淋淋菌性感染的范式变化方法

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Antimicrobial resistance in is a major issue of public health, and there is a critical need for the development of new antigonococcal strategies. In this study, we investigated the effectiveness of antimicrobial blue light (aBL; wavelength, 405 nm), an innovative nonpharmacological approach, for the inactivation of . . Our findings indicated that aBL preferentially inactivated , including antibiotic-resistant strains, over human vaginal epithelial cells in vitro. Furthermore, no aBL-induced genotoxicity to the vaginal epithelial cells was observed at the radiant exposure used to inactivate . aBL also effectively inactivated that had attached to and invaded into the vaginal epithelial cells in their cocultures. No gonococcal resistance to aBL developed after 15 successive cycles of inactivation induced by subtherapeutic exposure to aBL. Endogenous aBL-activatable photosensitizing porphyrins in were identified and quantified using ultraperformance liquid chromatography, with coproporphyrin being the most abundant species in all strains studied. Singlet oxygen was involved in aBL inactivation of . Together, these findings show that aBL represents a potential potent treatment for antibiotic-resistant gonococcal infection.

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