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首页> 美国卫生研究院文献>Antioxidants >Antioxidant Effects of Turmeric Leaf Extract against Hydrogen Peroxide-Induced Oxidative Stress In Vitro in Vero Cells and In Vivo in Zebrafish
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Antioxidant Effects of Turmeric Leaf Extract against Hydrogen Peroxide-Induced Oxidative Stress In Vitro in Vero Cells and In Vivo in Zebrafish

机译：姜黄叶提取物抗氧化型氧化胁迫在Vero细胞中体外氧化应激的抗氧化作用及斑马鱼体内体内

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Oxidative stress, caused by the excessive production of reactive oxygen species (ROS), results in cellular damage. Therefore, functional materials with antioxidant properties are necessary to maintain redox balance. Turmeric leaves (Curcuma longa L. leaves; TL) are known to have antioxidant properties, including 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and Hydrogen peroxide (H2O2) radical scavenging activity in several studies. The antioxidant effects of TL come from distinct bioactive compounds, such as curcumin, total phenolic compounds, and flavonoids. Therefore, in this study, the antioxidant effects of a water extract of TL (TLE) against H2O2 treatment were assessed in vitro Vero cells and in vivo zebrafish models. The intracellular ROS generation and the proportion of sub-G1 phase cells were evaluated in H2O2- or/and TLE-treated Vero cells to measure the antioxidant activity of TLE. TLE showed outstanding intracellular ROS scavenging activity and significantly decreased the proportion of cells in the sub-G1 phase in a dose-dependent manner. Furthermore, cell death, ROS generation, and lipid peroxidation in the H2O2-treated zebrafish model were attenuated as a consequence of TLE treatment. Collectively, the results from this study suggested that TLE may be an alternative material to relieve ROS generation through its antioxidant properties or a suitable material for the application in a functional food industry.
机译：由过量生产反应性氧物质（ROS）引起的氧化应激导致细胞损伤。因此，具有抗氧化性能的功能材料是保持氧化还原平衡所必需的。已知姜黄叶（Curcuma Longa L.叶子; T1）具有抗氧化性质，包括2,2-二苯基-1-富铬酰基（DPPH），2,2'-唑类二 - （3-乙基苯并噻唑啉）-6-磺酸酸（ABTS）和过氧化氢（H2O2）在几种研究中的自由基清除活性。 T1的抗氧化作用来自不同的生物活性化合物，如姜黄素，总酚类化合物和黄酮类化合物。因此，在本研究中，在体外Vero细胞和体内斑马鱼模型中评估了T1（TLE）水提取物对H 2 O 2处理的抗氧化效应。在H 2 O 2或/和TLE处理的vero细胞中评估细胞内ROS生成和亚g1相细胞的比例，以测量TLE的抗氧化活性。 TLE显示出优异的细胞内ROS清除活性，以剂量依赖性方式显着降低了亚g1相中的细胞比例。此外，在H 2 O 2处理的斑马鱼模型中，由于TLE处理而衰减了细胞死亡，ROS生成和脂质过氧化。统称，来自该研究的结果表明，TLE可以是通过其抗氧化性能或合适的材料在功能性食品工业中应用的替代材料来缓解ROS。

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