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8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists

机译:2S-Husperidin的8周补充剂调节运动后的抗氧化剂和炎症状态直到业余骑自行车者的用尽

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摘要

Both acute and chronic ingestion of 2S-hesperidin have shown antioxidant and anti-inflammatory effects in animal studies, but so far, no one has studied this effect of chronic ingestion in humans. The main objective was to evaluate whether an 8-week intake of 2S-hesperidin had the ability to modulate antioxidant-oxidant and inflammatory status in amateur cyclists. A parallel, randomized, double-blind, placebo-controlled trial study was carried out with two groups (500 mg/d 2S-hesperidin; n = 20 and 500 mg/d placebo; n = 20). An incremental test was performed to determine the working zones in a rectangular test, which was used to analyze for changes in antioxidant and inflammatory biomarkers. After 2S-hesperidin ingestion, we found in the rectangular test: (1) an increase in superoxide dismutase (SOD) after the exercise phase until exhaustion (p = 0.045) and the acute recovery phase (p = 0.004), (2) a decrease in the area under the oxidized glutathione curve (GSSG) (p = 0.016), and (3) a decrease in monocyte chemoattractant protein 1 (MCP1) after the acute recovery phase (p = 0.004), post-intervention. Chronic 2S-hesperidin supplementation increased endogenous antioxidant capacity (↑SOD) after maximal effort and decreased oxidative stress (↓AUC-GSSG) during the rectangular test, decreasing inflammation (↓MCP1) after the acute recovery phase.
机译:急性和慢性摄入2S-Husperidin两者都显示出抗氧化剂和动物研究中的抗炎作用,但到目前为止,没有人研究过人类慢性摄入的这种效果。主要目的是评估2S-Husperidin的8周摄入是否有能力调节抗氧化剂 - 氧化剂和业余骑自行车者的炎症状态。用两组(500mg / d 2s-herperidin; n = 20和500mg / d安慰剂进行平行,随机,双盲,安慰剂对照试验研究; n = 20)。进行增量测试以确定矩形试验中的工作区,用于分析抗氧化剂和炎症生物标志物的变化。在2S-Husperidin摄入后,我们发现在矩形测试中:(1)在运动阶段后超氧化物歧化酶(SOD)增加(P = 0.045)和急性回收相(P = 0.004),(2)a降低氧化谷胱甘肽曲线(GSSG)下的面积(P = 0.016),和(3)在急性回收相(P = 0.004)后单核细胞化学蛋白1(MCP1)降低(P = 0.004),干预后。慢性2S-Hosperidin补充在最大努力下提高内源性抗氧化能力(↑SOD),并在矩形试验期间降低氧化应激(↓AUC-GSSG),在急性回收阶段后降低炎症(↓MCP1)。

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