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Effect of Maternal Dietary Redox Levels on Antioxidative Status and Immunity of the Suckling Off-Spring

机译:母体膳食氧化还原水平对春季乳酸抗氧化状态及免疫力的影响

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摘要

This study investigates two levels of dietary selenium (Se) and vitamin E in combination on their status in sows and their progeny, and influence on antioxidant status and immunological responses of the piglets at weaning. Female pigs (n = 6) were provided LOW or HIGH antioxidant nutrition (Se and vitamin E) from mating until weaning of their off-spring. The HIGH treatment elevated the concentration of Se (p = 0.015) and α-tocopherol (p = 0.023) in plasma of piglets compared with piglets of the LOW treatment. Treatments also affected the concentrations of milk and sow plasma immunoglobulins. Piglets from sows on the HIGH treatment had increased (p < 0.001) activity of glutathione peroxidase, lower serum levels of C-reactive protein (p = 0.005), haptoglobin (p = 0.05) and albumin (p = 0.05), and the number of white blood cells (p = 0.023) and the ratio of NEU to LYM was lower (p = 0.025) than in piglets from sows on the LOW group. Furthermore, the dietary antioxidant level influenced responses of cytokines (interleukine (IL) 6 (p = 0.007), 12 (p = 0.01) and 18 (p = 0.01)) in piglets’ plasma. In conclusion, improved antioxidant status via dietary maternal provision improves the robustness of the offspring via immunomodulatory mechanisms.
机译:本研究研究了两种水平的硒硒(SE)和维生素E,组合其母猪及其后代的地位,以及对断奶仔猪的抗氧化状态和免疫应答的影响。雌性猪(n = 6)从配合,直至春天的断开,提供低或高抗氧化营养(SE和维生素E)。与低处理的仔猪相比,高处理升高了仔猪血浆中SE(p = 0.015)和α-生育酚(P = 0.023)的浓度。治疗也影响了牛奶和母猪血浆免疫球蛋白的浓度。从高处理母猪的仔猪增加(p <0.001)谷胱甘肽过氧化物酶的活性,降低血清水平的C反应蛋白(P = 0.005),哈达氟胺(P = 0.05)和白蛋白(P = 0.05),以及数量白细胞(P = 0.023)和Neu至Lym的比率低于低组织母猪的仔猪(p = 0.025)。此外,仔猪血浆中的细胞因子(白细胞核(IL)6(P = 0.007),12(P = 0.01)和18(p = 0.01))的膳食抗氧化水平影响。总之,通过膳食母体提供改善的抗氧化物状况通过免疫调节机制改善了后代的鲁棒性。

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