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首页> 美国卫生研究院文献>Bioengineering >Sol-Gel Derived Hydroxyapatite Coatings for Titanium Implants: A Review
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Sol-Gel Derived Hydroxyapatite Coatings for Titanium Implants: A Review

机译：溶胶 - 凝胶衍生钛植入物的羟基磷灰石涂料：综述

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摘要

With the growing demands for bone implant therapy, titanium (Ti) and its alloys are considered as appropriate choices for the load-bearing bone implant substitutes. However, the interaction of bare Ti-based implants with the tissues is critical to the success of the implants for long-term stability. Thus, surface modifications of Ti implants with biocompatible hydroxyapatite (HAp) coatings before implantation is important and gained interest. Sol-gel is a potential technique for deposition the biocompatible HAp and has many advantages over other methods. Therefore, this review strives to provide widespread overview on the recent development of sol-gel HAp deposition on Ti. This study shows that sol-gel technique was able to produce uniform and homogenous HAp coatings and identified the role of surface pretreatment of Ti substrate, optimizing the sol-gel parameters, substitution, and reinforcement of HAp on improving the coating properties. Critical factors that influence on the characteristics of the deposited sol-gel HAp films as corrosion resistance, adhesion to substrate, bioactivity, morphological, and structural properties are discussed. The review also highlights the critical issues, the most significant challenges, and the areas requiring further research.
机译：With the growing demands for bone implant therapy, titanium (Ti) and its alloys are considered as appropriate choices for the load-bearing bone implant substitutes.然而，裸TI基植入物与组织的相互作用对于植入物的成功对于长期稳定性至关重要。因此，在植入前具有生物相容性羟基磷灰石（HAP）涂层的Ti植入物的表面修饰是重要的并且获得的感兴趣。溶胶 - 凝胶是用于沉积生物相容性HAP的潜在技术，并且具有与其他方法的许多优点。因此，本综述致力于提供普遍存在的概述Ti上溶胶 - 凝胶Hap沉积的最新发展。该研究表明，溶胶 - 凝胶技术能够生产均匀和均匀的Hap涂层，并确定了Ti衬底的表面预处理的作用，优化了HAP改善涂层性能的溶胶 - 凝胶参数，取代和增强。讨论了对沉积溶胶 - 凝胶Hap膜的特性影响沉积溶胶 - 凝胶Hap膜的特性的关键因素讨论了对底物，生物活性，形态学和结构性能的粘附性。审查还突出了关键问题，最重要的挑战以及需要进一步研究的领域。

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