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首页> 美国卫生研究院文献>International Journal of Nanomedicine >Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
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Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants

机译：钛上的仿生螺旋玫瑰形纳米管和纳米晶羟基磷灰石涂层用于改善整形外科植入物

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摘要

Natural bone consists of hard nanostructured hydroxyapatite (HA) in a nanostructured protein-based soft hydrogel template (ie, mostly collagen). For this reason, nanostructured HA has been an intriguing coating material on traditionally used titanium for improving orthopedic applications. In addition, helical rosette nanotubes (HRNs), newly developed materials which form through the self-assembly process of DNA base pair building blocks in body solutions, are soft nanotubes with a helical architecture that mimics natural collagen. Thus, the objective of this in vitro study was for the first time to combine the promising attributes of HRNs and nanocrystalline HA on titanium and assess osteoblast (bone-forming cell) functions. Different sizes of nanocrystalline HA were synthesized in this study through a wet chemical precipitation process following either hydrothermal treatment or sintering. Transmission electron microscopy images showed that HRNs aligned with nanocrystalline HA, which indicates a high affinity between both components. Some of the nanocrystalline HA formed dense coatings with HRNs on titanium. More importantly, results demonstrated enhanced osteoblast adhesion on the HRNanocrystalline HA-coated titanium compared with conventional uncoated titanium. Among all the HRNanocrystalline HA coatings tested, osteoblast adhesion was the greatest when HA nanometer particle size was the smallest. In this manner, this study demonstrated for the first time that biomimetic HRNanocrystalline HA coatings on titanium were cytocompatible for osteoblasts and, thus, should be further studied for improving orthopedic implants.
机译：天然骨骼由纳米结构的基于蛋白质的软水凝胶模板（即主要为胶原蛋白）中的硬纳米结构的羟基磷灰石（HA）组成。由于这个原因，纳米结构的HA一直是传统上使用的钛上引人入胜的涂料，用于改善骨科应用。此外，螺旋玫瑰花碳纳米管（HRN）是通过在身体溶液中通过DNA碱基对构件的自组装过程而形成的新开发材料，是具有模仿天然胶原蛋白的螺旋结构的柔软纳米管。因此，这项体外研究的目的是第一次将HRNs和纳米晶HA在钛上的有希望的特性结合起来，并评估成骨细胞（成骨细胞）的功能。在这项研究中，通过水热处理或烧结后的湿化学沉淀工艺合成了不同尺寸的纳米晶HA。透射电子显微镜图像显示，HRNs与纳米晶HA对齐，表明这两个组分之间的亲和力高。一些纳米晶HA在钛上形成了带有HRN的致密涂层。更重要的是，结果表明与常规的未涂覆钛相比，HRN /纳米晶HA涂覆的钛具有增强的成骨细胞粘附力。在所有测试的HRN /纳米晶体HA涂层中，当HA纳米粒径最小时，成骨细胞粘附力最大。通过这种方式，这项研究首次证明了仿生HRN /纳米晶HA涂层对成骨细胞具有细胞相容性，因此应进一步研究以改善整形外科植入物。

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