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首页> 外文期刊>Biomaterials >Helical rosette nanotubes: A biomimetic coating for orthopedics?
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Helical rosette nanotubes: A biomimetic coating for orthopedics?

机译：螺旋形玫瑰花碳纳米管：骨科仿生涂层？

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Helical rosette nanotubes (HRN) are obtained through an entropically driven self-assembly process of low-molecular-weight synthetic modules under physiological conditions. Counter-intuitively, these materials undergo extensive self-assembly under the effect of temperature, resulting in networks of very long nanotubes. We have previously shown, using an in vitro model, that titanium (Ti) coated with HRN containing a lysine side chain (HRN-K1) displayed enhanced osteoblast (OB) adhesion when compared to uncoated Ti (p < 0.01). Because it has been widely known that proteins play a critical role in OB adhesion on nanophase materials, here we examine OB adhesion on heated (+T) and unheated (-T) HRN-K1-coated Ti under serum (+S, presence of proteins) and serum-free (-S, absence of proteins) conditions. The results demonstrated that (a) while proteins enhanced OB adhesion on +T HRN-K1-coated Ti, they had no effect on -T HRN-K1-coated Ti, suggesting an active role played by the rosette nanotubes in promoting OB adhesion, and (b) under -S conditions, +T HRN-K1 induced the same level of OB adhesion as uncoated Ti under +S conditions, suggesting that +T HRN-K1 acts as a protein substitute. Finally, transmission electron microscopy and atomic force microscopy studies of +T and -T HRN-K1-coated Ti revealed a significant change in surface coverage, density and hierarchical organization of the nanotubes upon heating, which was correlated with their ability to promote cell adhesion. (c) 2005 Elsevier Ltd. All rights reserved.
机译：螺旋玫瑰形碳纳米管（HRN）是通过在生理条件下低分子量合成模块的熵驱动自组装过程获得的。违反直觉，这些材料在温度的作用下会发生广泛的自组装，从而形成非常长的纳米管网络。我们先前已经使用体外模型显示，与未涂覆的Ti相比，涂有含赖氨酸侧链（HRN-K1）的HRN的钛（Ti）表现出增强的成骨细胞（OB）粘附性（p <0.01）。由于众所周知蛋白质在纳米相材料的OB粘附中起关键作用，因此我们在血清（+ S，存在以下情况下，我们研究了在加热（+ T）和未加热（-T）HRN-K1涂层的Ti上的OB粘附。蛋白质）和无血清（-S，无蛋白质）条件。结果表明：（a）尽管蛋白质增强了+ T HRN-K1涂层的Ti的OB粘附力，但对-T HRN-K1涂层的Ti没有影响，这表明玫瑰花状纳米管在促进OB粘附性方面发挥了积极作用， （b）在-S条件下，+ T HRN-K1在+ S条件下与未涂覆的Ti诱导的OB粘附水平相同，表明+ T HRN-K1可以作为蛋白质替代物。最后，对+ T和-T HRN-K1涂层的Ti进行的透射电子显微镜和原子力显微镜研究表明，加热后纳米管的表面覆盖率，密度和分层组织发生了显着变化，这与它们促进细胞粘附的能力有关。 （c）2005 Elsevier Ltd.保留所有权利。

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