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首页> 美国卫生研究院文献>Brain Sciences >Mismatch Negativity and Loudness Dependence of Auditory Evoked Potentials among Patients with Major Depressive Disorder Bipolar II Disorder and Bipolar I Disorder
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Mismatch Negativity and Loudness Dependence of Auditory Evoked Potentials among Patients with Major Depressive Disorder Bipolar II Disorder and Bipolar I Disorder

机译：在主要抑郁症双相症和双相紊乱的患者中听觉诱发电位的失配和响度依赖性

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Mismatch negativity (MMN) and loudness dependence of auditory evoked potentials (LDAEP), which are event-related potentials, have been investigated as biomarkers. MMN indicates the pre-attentive function, while LDAEP may be an index of central serotonergic activity. This study aimed to test whether MMN and LDAEP are useful biological markers for distinguishing patients with bipolar disorder (BD) and major depressive disorder (MDD), as well as the relationship between MMN and LDAEP. Fifty-five patients with major depressive episodes, aged 20 to 65 years, who had MDD (n = 17), BD type II (BIID) (n = 27), and BD type I (BID) (n = 11), were included based on medical records. Patients with MDD had a higher MMN amplitude than those with BID. In addition, the MMN amplitude in F4 positively correlated with the Korean version of mood disorder questionnaire scores (r = 0.37, p = 0.014), while the MMN amplitude in F3 correlated negatively with LDAEP (r = −0.30, p = 0.024). The odds ratios for the BID group and some variables were compared with those for the MDD group using multinomial logistic regression analysis. As a result, a significant reduction of MMN amplitude was found under BID diagnosis compared to MDD diagnosis (p = 0.015). This study supported the hypothesis that MMN amplitude differed according to MDD, BIID, and BID, and there was a relationship between MMN amplitude and LDAEP. These findings also suggested that BID patients had a reduced automatic and pre-attentive processing associated with serotonergic activity or N-methyl-D-aspartate receptor.
机译：被调查作为生物标志物进行了与事件相关电位的听觉诱发电位（LDAEP）的失配消极性（MMN）和响度依赖性。 MMN表示预关节功能，而LDAEP可能是中央血清奈良能活性的指标。本研究旨在测试MM​​N和LDAEP是否是用于区分双相障碍（BD）和主要抑郁症（MDD）的患者的有用生物标志物，以及MMN和LDAEP之间的关系。患有MDD（n = 17），BD型II（BIID）（N = 27）和BD I类（N = 27）的55岁的主要抑郁发作患者，患有MDD（N = 17），BD II（BIAD）（BID）（n = 11）包括基于医疗记录。 MDD的患者具有比具有出价的MMN振幅更高。此外，F4中的MMN幅度与韩国形态障碍问卷评分（r = 0.37，p = 0.014）呈正相关（r = 0.37，p = 0.014），而F3中的MMN振幅与LDAEP（r = -0.30，p = 0.024负相关。将BID组和一些变量的差距与使用多项逻辑回归分析进行比较。结果，与MDD诊断相比，BID诊断下发现了MMN振幅的显着降低（P = 0.015）。本研究支持了MMN振幅根据MDD，BIID和出价不同的假设，并且MMN振幅和LDAEP之间存在关系。这些发现还表明，出价患者具有减少的自动和预分子加工，与血清onOronergic活性或N-甲基-D-天冬氨酸受体相关。

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