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首页> 美国卫生研究院文献>Clinical Psychopharmacology and Neuroscience >Successful Treatment of Psychiatric Symptoms after Traumatic Brain Injury Using Deep Brain Stimulation to the Anterior Limb of Internal Capsule-Nucleus Accumbens
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Successful Treatment of Psychiatric Symptoms after Traumatic Brain Injury Using Deep Brain Stimulation to the Anterior Limb of Internal Capsule-Nucleus Accumbens

机译：创伤性脑损伤后的精神症状成功治疗使用深脑刺激对内部胶囊核的前肢刺激

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摘要

Psychiatric symptoms are common after traumatic brain injury (TBI), and some patients have poor drug therapeutic efficacy. We report a successfully treated case of psychiatric symptoms after TBI using deep brain stimulation (DBS) to the anterior limb of internal capsule (ALIC)-nucleus accumbens (NAc) in a 76-year-old woman. The patient suffered from auditory hallucination, mood changes, and insomnia caused by TBI. Psychological test assessment showed the scores of Hamilton Anxiety Scale, Hamilton Depression Scale and Positive and Negative Syndrome Scale were 30, 35, and 96 respectively. Head magnetic resonance imaging scan showed right temporal lobe encephalomalacia. Head magnetic resonance spectroscopy (MRS) showed bilateral basal ganglia choline increased relatively. After DBS to the ALIC-NAc, the target parameters were adjusted. The psychiatric symptoms were completely improved and the result of head MRS was normal in the end. The current report declares that DBS is reversible, adjustable and safe in the treatment of psychiatric symptoms caused by TBI. DBS to the ALIC-NAc should be considered as a possible treatment choice once a patient showed psychiatric symptoms after TBI.
机译：心理脑损伤（TBI）后，精神症状是常见的，有些患者药物治疗疗效差。在一个76岁的女性中，使用深脑刺激（DBS）向内部胶囊（ALIC） - 核心（NAC）的前肢（DB）举行成熟处理的精神症状案例。患者受到听觉幻觉，情绪变化和TBI引起的失眠。心理测试评估显示汉密尔顿焦虑尺度的分数，汉密尔顿抑郁症和正面和负综合征等级分别为30,35和96。头部磁共振成像扫描显示右颞叶脑脑癌。头部磁共振光谱（MRS）显示双侧基底神经节胆碱相对增加。 DBS至Alic-NAC后，调节靶参数。精神症状完全改善，头部MRS的结果最终是正常的。目前的报告宣布DBS是可逆的，可调和安全的TBI造成的精神症状。一旦患者在TBI后表现出精神病症状，就应该将DBS视为可能的治疗选择。

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