首页> 美国卫生研究院文献>Contemporary Clinical Trials Communications >The role of a traditional and western diet on glucose homeostasis in Greenlandic Inuit carriers and non-carriers of type 2 diabetes variant in the TBC1D4 gene: A protocol for a randomized clinical trial
【2h】

The role of a traditional and western diet on glucose homeostasis in Greenlandic Inuit carriers and non-carriers of type 2 diabetes variant in the TBC1D4 gene: A protocol for a randomized clinical trial

机译:传统和西方饮食在TBC1D4基因中的2型糖尿病变种的格陵兰因因子载体和非载体中的作用:随机临床试验的议定书

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

The lifestyle of Inuit in Greenland and worldwide is undergoing a transition from a fisher-hunter to a westernized society and meanwhile the prevalence of type-2 diabetes (T2D) has increased dramatically. Studies have shown that a common nonsense p.Arg684Ter variant in TBC1D4, which is frequent in Greenland, confers genetic susceptibility towards high risk of T2D. The aim of the study is to investigate whether a traditional marine diet, with high fat and low carbohydrate, will improve glycemic control in Greenland Inuit compared to a western diet. Moreover, we want to examine if the response is more pronounced in carriers of the p.Arg684Ter variant.
机译:在格陵兰岛和全球范围内的因纽特人的生活方式正在从渔民猎人到西化社会的过渡,同时,2型糖尿病(T2D)的患病率急剧增加。研究表明,TBC1D4中常见于格陵兰频繁的常见非义的P.Arg684变体赋予高风险的遗传敏感性。该研究的目的是调查传统海洋饮食是否具有高脂肪和低碳水化合物,将在与西方饮食相比,改善格陵兰因纽特人的血糖控制。此外,我们想检查P.Arg684ter变体的载体中响应是否更加明显。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号