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首页> 美国卫生研究院文献>Dermatology and Therapy >Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin
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Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin

机译：更年期和皮肤：旧的最爱和在化妆品中的新创新用于雌激素缺乏皮肤

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Estradiol levels decline to near zero after menopause. Estrogen deficiency adversely affects many physiological functions, including skin changes such as atrophy, wrinkles, hydration, poor wound healing/barrier function, decline in perceived facial attractiveness, and even psychological health. Women with menopausal skin changes seek cosmetic and medical treatments that enhance their self-perception and inhibit skin aging, particularly in exposed areas (face, neck, and hands). It is widely accepted that traditional treatments such as local hormone treatment are effective in reversing (estrogen-deficient) aging skin deterioration. But, the uncertainly of the effects of long-term systemic menopausal treatment and, more recently, aversion to systemic hormones has led to newer therapeutic agents that can send estrogen’s important skin-health signals via selective estrogen receptor modulators (SERMs) other than estrogen itself. Many plant-derived compounds (phytoestrogens) that contain estrogen-agonist SERMs now play major roles in treatments for aging and estrogen-deficient skin. The targets are the estrogen receptor beta molecules that are abundant in skin (keratinocytes/fibroblasts). The variation in effect and the influence of coexisting influences such as environmental exposure, race, and aging are reviewed. While several botanicals are mentioned in this overview, two promising cosmeceuticals are examined, an analog of resveratrol [4′-acetoxy resveratrol (4AR)], which enjoys a high public profile in the health arena, and the isoflavonoid compound equol. Both 4AR and equol are SERMs that have peer-reviewed in vitro and clinical study results supporting improvement of estrogen-deficient menopausal skin.
机译：绝经后雌二醇水平下降到零附近。雌激素缺乏对许多生理功能产生不利影响，包括皮肤变化，如萎缩，皱纹，水合，伤口愈合/屏障功能差，感知面部吸引力下降，甚至心理健康。长期性皮肤的妇女改变寻求化妆品和医疗治疗，增强其自我感知和抑制皮肤衰老，特别是在暴露区域（面部，颈部和手）。众所周知，传统治疗如局部激素治疗，可有效逆转（雌激素缺乏）老化皮肤劣化。但是，不确定长期全身性长期治疗的影响，最近，厌恶全身激素的厌恶导致了更新的治疗剂，可以通过除雌激素本身以外的选择性雌激素受体调节剂（SERM）发送雌激素的重要皮肤健康信号。许多含有雌激素激动剂SERMS的植物衍生的化合物（植物雌激素）现在在治疗中发挥主要作用，用于衰老和雌激素缺乏皮肤。靶标是皮肤（角质形成细胞/成纤维细胞）丰富的雌激素受体β分子。综述了效果的变化和共存影响，如环境暴露，种族和老龄化。虽然在这一概述中提到了几种植物，但检查了两个有前途的化妆品，这是白藜芦醇的类似物[4'-乙酰氧基白藜芦醇（4AR）]，它在健康竞技场中享有高公共轮廓，并且异黄酮化合物等较高。 4AR和EQUOL都是SERMS，其在体外进行同行评审，临床研究结果支持改善雌激素缺乏更年期皮肤。

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