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首页> 美国卫生研究院文献>Diagnostics >Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus
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Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus

机译：角膜地球像理性质与生物力学参数的关系源自突发菌的动态双向空气施加测量过程

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摘要

The morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert). It included 109 eyes from 109 patients (aged between 18 and 69 years) with a diagnosis of keratoconus (KC) who underwent a complete eye examination including a comprehensive corneal topographic analysis with the Sirius system (CSO). With the topographic information obtained, a morphogeometric and volumetric analysis was performed, defining different variables of clinical use. CH and CRF were found to be correlated with these variables, but this correlation was highly influenced by corneal thickness. This suggests that the mechanical properties of KC cornea contribute only in a partial and limited manner to these biomechanical parameters, being mostly influenced by morphogeometry under normal intraocular pressure levels. This would explain the limitation of CH and CRF as diagnostic tools for the detection of incipient cases of KC.
机译：角膜结构的形态诊断分析已成为角蛋白酶（KC）的临床相关诊断程序，以及角膜生物力学性能的体内评价。然而，这两种类型的度量之间的关系仍然不太了解。目前的研究调查了角膜形态学测定和体积与两个生物力学参数的关系：角膜滞后（CH）和角膜抵抗因子（CRF），由眼响应分析仪（Reichert）提供。它包括109名患者（年龄在18至69岁之间）的眼睛，诊断了Keratoconus（KC），他经历了完整的眼科检查，包括与Sirius系统（CSO）的全面角膜地形分析。利用所获得的地形信息，进行了定义和体积分析，定义了不同的临床使用变量。发现CH和CRF与这些变量相关，但这种相关性受到角膜厚度的高度影响。这表明KC角膜的力学性质仅以部分和有限的方式贡献这些生物力学参数，主要受到正常的眼压水平下的Morphogeometry的影响。这将解释CH和CRF作为检测初期KC初期诊断工具的限制。

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