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Establishing a proof of concept for the effects of low-carbohydrate high-fat diet (LCHFD) and physical activity on body composition in type 2 diabetes

机译:建立低碳水化合物高脂饮食(LCHFD)和身体活动在2型糖尿病中的身体活动的概念证明

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摘要

Overweight and obesity are both a risk factor for developing and exacerbating type 2 diabetes (T2D). While the most common diet used to treat overweight and obesity focus on high-carbohydrate, low-fat, energy deficit diets, recently, low-carbohydrate, high-fat diets (LCHFD) have become popular in targeting obesity. This proof-of-concept study attempted to determine if an LCHFD could improve body composition variables, or if a concurrent treatment of LCHFD and physical activity would create an interference effect in individuals with T2D. Overweight and obese with T2D (n = 39) were assigned into either a 16-week combined physical activity and LCHFD group (ConG), LCHFD-only group (DieG) or control group (NonG). No statistically significant (p > 0.01) changes were found in body mass in the ConG (2.0%, F = 0.039, P = 0.846) and DieG (2.5%, F = 0.188, P = 0.669); for body mass index in the ConG (2.2%, F = 0.046, P = 0.832) and DieG (2.3%, F = 0.098, P = 0.758.); and waist-to-hip ratio in the ConG (0%, F = 0.002, P = 0.968) and DieG (0%, F = 0.023, P = 0.882). However, clinically significant changes were observed in HbA1c in the ConG male group (23% decrease); percentage body fat for the ConG (16.7%, F = 1.682, P = 0.208, g = 0.534) and DieG (13.0%, F = 0.638, P = 0435, g = 0.361); for waist circumferences in the ConG (5.4%, F = 0.686, P = 0.416, g = 0.341) and DieG (6.3%, F = 1.327, P = 0.264, g = 0.520); and for hip circumference in the ConG (5.8%, F = 0.993, P = 0.329, g = 0.410) and DieG (7.0%, F = 2.668, P = 0.119, g = 0.737). Results indicate that moderate clinically significant changes in body composition are achievable with LCHFD and/or daily walking in obese adults living with T2D. However, more robust research is required to determine the effects of LCHFD, with or without concurrent physical activity, on obesity and other diabetic complication markers.
机译:超重和肥胖是发展和加剧2型糖尿病(T2D)的危险因素。虽然用于治疗超重和肥胖的最常见饮食重点关注高碳水化合物,低脂肪,能量缺陷饮食,最近,低碳水化合物,高脂饮食(LCHFD)在靶向肥胖方面变得流行。这种概念证据研究试图确定LCHFD是否可以改善身体成分变量,或者如果LCHFD和身体活动的同时治疗将在具有T2D的个体中产生干扰效果。将T2D(n = 39)的超重和肥胖分配成16周组合的身体活性和LCHFD组(CONG),仅限LCHFD组(Dieg)或对照组(Nong)。在孔中没有统计学意义(p> 0.01)变化(2.0%,f = 0.039,p = 0.846)和椎板(2.5%,f = 0.188,p = 0.669);对于锥体中的体重指数(2.2%,F = 0.046,P = 0.832)和叶片(2.3%,F = 0.098,P = 0.758);和凹凸(0%,F = 0.002,p = 0.968)和椎板(0%,F = 0.023,P = 0.882)中的腰背率比。然而,在锥体男组的HBA1C中观察到临床上显着的变化(23%的减少);孔百分比的体脂肪(16.7%,f = 1.682,p = 0.208,g = 0.534)和椎体(13.0%,f = 0.638,p = 0435,g = 0.361);对于孔中的腰圆周(5.4%,F = 0.686,P = 0.416,G = 0.341)和椎板(6.3%,F = 1.327,P = 0.264,G = 0.520);并且对于孔中的臀周长(5.8%,f = 0.993,p = 0.329,g = 0.410)和椎体(7.0%,f = 2.668,p = 0.119,g = 0.737)。结果表明,适度的身体组合物的临床显着变化是可实现的,患有LCHFD和/或在与T2D一起生活的肥胖成年人中散步。然而,需要更肥大的研究来确定LCHFD,或不具有并发身体活动的影响,肥胖症和其他糖尿病并发症标志物。

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