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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Visual Parameters and Retinal Morphology for Polypoidal Choroidal Vasculopathy Pre- and Post-Intravitreal Ranibizumab with or without Photodynamic Therapy: A Short-Term Prospective Study
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Visual Parameters and Retinal Morphology for Polypoidal Choroidal Vasculopathy Pre- and Post-Intravitreal Ranibizumab with or without Photodynamic Therapy: A Short-Term Prospective Study

机译：具有或不具有光动力治疗的脊髓灰质脉络膜血管病的视觉参数和视网膜形态有或没有光动力治疗：短期前瞻性研究

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The objective of this study was to compare visual parameters and retinal layers’ morphology pre-treatment (baseline) and 6 months post-treatment in polypoidal choroidal vasculopathy (PCV) eyes. A single centre, longitudinal, prospective study was conducted at a public tertiary hospital of Malaysia. Visual parameters including distance and near visual acuity (DVA and NVA), contrast sensitivity (CS), reading speed (RS), and different qualitative and quantitative optical coherence tomography (OCT) parameters were evaluated pre- and 6 months post-treatment. Thirty-three naïve PCV eyes of 32 patients (mean age of 67.62 years) were evaluated pre- and post-treatment of intravitreal ranibizumab with and without photodynamic therapy. After treatment, sub retinal fluid decreased from 27 eyes (84.35%) at baseline to 7 eyes (21.88%) at 6 months while pigment epithelium detachment decreased from 32 eyes (100%) at base line to 15 eyes (46.87%) at 6 months. Mean pre-treatment quantitative morphological OCT retinal parameters including thickness and volume of central sub field, center thickness, center minimum, and maximum thickness reduced significantly. Similarly, all visual parameters including DVA, NVA, CS, and RS showed statistically significant improvement. While 89% of the eyes showed improvement in CS, 78%, 71%, and 65% of the eyes showed improvement in NVA, RS, and DVA, respectively. Thus, CS was the most treatment responsive visual parameter.
机译：本研究的目的是比较视觉参数和视网膜层的形态预处理（基线）和6个月在息肉内脉络膜血管病（PCV）眼后处理后治疗。在马来西亚公共大三医院进行了单一中心，纵向前瞻性研究。视觉参数包括距离和近视敏度（DVA和NVA），对比度灵敏度（CS），读取速度（RS）和不同的定性和定量光学相干断层扫描（OCT）参数进行治疗后6个月，6个月。 32例患者的32名幼稚PCV眼（平均年龄为67.62岁），并在玻璃体内Ranibizumab与术前治疗和无光动力治疗。治疗后，亚视网膜流体在6个月内以基线（21.88％）在基线上（84.35％）下降（84.35％），同时颜料上皮脱离从碱基线的32只眼（100％）降低至15只眼睛（46.87％）几个月。平均预处理定量形态学OCT视网膜参数，包括中央子场，中心厚度，中心最小值和最大厚度的厚度和体积显着减小。同样，所有视觉参数，包括DVA，NVA，CS和RS都显示出统计上显着的改进。虽然89％的眼睛表现出CS，78％，71％和65％的眼睛的改善，分别显示了NVA，RS和DVA的改善。因此，CS是最敏感的视觉参数。

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