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首页> 外文会议>Optics in health care and biomedical optics IV >Measurements of retinal temperature increase during photodynamic therapy for choroidal neovascularization
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Measurements of retinal temperature increase during photodynamic therapy for choroidal neovascularization

机译：脉络膜新生血管光动力治疗期间视网膜温度升高的测量

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To study the risk of retinal thermal injury from 532 nm laser during photodynamic therapy (PDT) for choroidal neovascularization (CNV) by measuring the retinal temperature increase of rabbit eyes. A microthermocouple technique was developed to measure retinal temperature increase during PDT in pigmented and non-pigmented rabbit eyes. The 532 nm laser exposures were performed with 100-s duration, 2-mm spot size, and retinal irradiance ranging from 400 to 1600 mW/cm~2. A K-type microthermocouple was inserted through the sclerotomy and advanced until the tip reached the retina at the posterior pole. The thermocouple was connected a computer that recorded and analyzed retinal temperature data. The results showed that the retinal temperature increase during laser exposure was proportional to retinal irradiance with a particular spot diameter, exposure duration, wavelength, and fundus pigmentation. And the measured retinal temperature increases in pigmented rabbits were a little higher than those in albino rabbits under the same radiant condition. Retinal threshold irradiance required for visible lesions at laser wavelength of 532 nm with 2.0-mm spot size and 100-s duration was 1657 mW/cm~2 in albino and 1003 mW/cm~2 in pigmented rabbits, respectively, corresponding to retinal temperature increase of about 8℃ and 6 ℃. The measured temperatures in albino and pigmented rabbit eyes were both lower than the model predictions, especially in pigmented rabbits. Therefore, further parameter modifying should be performed to obtain accuracy prediction of retinal temperature.
机译：通过测量兔眼的视网膜温度升高，研究在532 nm激光进行光动力疗法（PDT）进行脉络膜新生血管（CNV）时视网膜热损伤的风险。开发了一种微热电偶技术来测量有色和无色兔眼PDT过程中的视网膜温度升高。进行532 nm激光照射的持续时间为100秒，光斑大小为2 mm，视网膜辐照度为400至1600 mW / cm〜2。将K型微热电偶插入硬膜切开术，并前进直至尖端到达后极处的视网膜。将热电偶连接到一台记录并分析视网膜温度数据的计算机。结果表明，激光照射期间视网膜温度升高与视网膜辐照度成正比，并具有特定的光斑直径，照射持续时间，波长和眼底色素沉着。在相同的辐射条件下，有色兔子的视网膜温度升高幅度要高于白化兔子。对应于视网膜温度，在532 nm的激光波长下，白斑病的斑点直径为2.0 mm，持续时间为100 s时，可见病变的视网膜阈值辐照度分别为1657 mW / cm〜2和有色兔子为1003 mW / cm〜2增加约8℃和6℃。在白化病和有色兔子的眼睛中测得的温度均低于模型预测值，尤其是在有色兔子中。因此，应进行进一步的参数修改以获得视网膜温度的准确预测。

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