• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on Optics in Health Care and Biomedical Optics >Theoretical investigation of thermal retinal response to photodynamic therapy for choroidal neovascularization
【24h】

Theoretical investigation of thermal retinal response to photodynamic therapy for choroidal neovascularization

机译：脉络膜新生血管化光动力治疗热视网膜响应的理论研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To study the risk of thermal injury in photodynamic therapy for choroidal neovascularization by calculating the retinal temperature of rabbits, a mathematical model for laser induced thermal effect on retina was developed. Homogeneous layer retinal models of different pigmented rabbits were presented to analyze the light distribution. The finite element method realized by Matlab software was used to solve classical bio-heat transfer model -^sPennis equation, in which heat loss due to choroidal blood flow was considered. The retinal temperature was calculated with different laser parameters, including different wavelengths (532nm, 578nm and 690nm), power density (200～1600 mW/cm~2), spot diameter (1mm, 2mm and 3mm) and different pigmented eye fundi. The prediction results showed the retinal temperature increased first, then reached maximum in a few seconds and kept constant during laser irradiation. Once laser exposure ended, the temperature decreased quickly to normal. With the increase of laser power density and spot size, the retinal temperature raised too. The temperature reduced exponentially with the distance from laser spot increased. The maximum temperature of non-pigmented rabbits was lower than that of pigmented rabbits. The temperature induced by 578nm laser irradiation was highest, the next was by 532nm laser and the lowest was by 690nm laser. For current parameters used to treat choroidal neovascularization (690nm, 600mW, 2mm, 83 sec), the maximum retinal temperature calculated was less than 45 °C, which indicating no thermal damage induced.
机译：为了通过计算兔子的视网膜温度来研究对脉络膜新生血管的热敏损伤的风险，开发了一种激光诱导的视网膜热效应的数学模型。提出了不同着色的兔子的均匀层视网膜模型以分析光分布。 MATLAB软件实现的有限元方法用于解决经典生物传热模型 - ^ SPENNIS方程，其中考虑了由脉络膜血流引起的热量损失。用不同的激光参数计算视网膜温度，包括不同的波长（532nm，578nm和690nm），功率密度（200〜1600mW / cm〜2），点直径（1mm，2mm和3mm）和不同的着色眼底基础。预测结果表明，视网膜温度首先增加，然后在几秒钟内达到最大值并在激光照射期间保持恒定。一旦激光曝光结束，温度迅速降低到正常。随着激光功率密度和光斑尺寸的增加，视网膜温度也升高。随着激光点的距离增加，温度呈指数增长。非颜料兔的最高温度低于着色兔的最高温度。由578nm激光照射诱导的温度最高，接下来是532nm激光，最低的是690nm激光。对于用于治疗脉络膜新生血管的电流参数（690nm，600mW，2mm，83秒），计算的最大视网膜温度小于45°C，这表明没有引起热损坏。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号