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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Long-Term Effects of Continuous Positive Airway Pressure (CPAP) Therapy on Obesity and Cardiovascular Comorbidities in Patients with Obstructive Sleep Apnea and Resistant Hypertension—An Observational Study
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Long-Term Effects of Continuous Positive Airway Pressure (CPAP) Therapy on Obesity and Cardiovascular Comorbidities in Patients with Obstructive Sleep Apnea and Resistant Hypertension—An Observational Study

机译：连续阳性气道压力（CPAP）治疗对阻塞性睡眠呼吸暂停患者肥胖和心血管合并的长期影响及抗性高血压 - 一种观察研究

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Background: We sought to investigate whether long-term continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA) and resistant hypertension (RHTN) could attenuate the cardiovascular disease risk by lowering their body-mass index (BMI). Methods: This was a long-term observational study of RHTN patients diagnosed with OSA. Patients were evaluated with polysomnography initially and after a mean follow-up period of four years. The patients were divided into two groups based on their compliance to CPAP therapy. Results: 33 patients (aged 54.67 ± 7.5, 18 men, 54.5%) were included in the study, of which 12 were compliant to CPAP therapy. A significant reduction in BMI at follow-up was noted in patients compliant to CPAP therapy (1.4 ± 3.5 vs. −1.6 ± 2.5, p = 0.006). We also noted a large effect size reduction in abdominal circumference at follow-up in the CPAP group. At follow-up evaluation, the mean heart rate (b/min) was lower in the CPAP group (58.6 ± 9.5 vs. 67.8 ± 7.8), while arrhythmia prevalence increased between initial (28.6%) and follow-up (42.9%) evaluation with an intermediate effect size in non-compliant patients. Conclusions: In our cohort of OSA patients with RHTN, long-term adherence to CPAP therapy was associated with weight loss and improvement in cardiac rhythm outcomes.
机译：背景：我们试图调查阻塞性睡眠呼吸暂停（OSA）和抗性高血压（RHTN）患者中的长期连续正气道压力（CPAP）治疗是否可以通过降低体重指数（BMI）来衰减心血管疾病风险。方法：这是诊断患有OSA的rhTN患者的长期观察研究。最初和平均随访时间为四年后用多肌瘤评估患者。将患者分为两组，基于其对CPAP治疗的依从性。结果：在研究中，33例患者（年龄54.67±7.5,18人，54.5％），其中12名符合CPAP疗法。在符合CPAP疗法的患者中注意到，符合CPAP治疗的患者（1.4±3.5±1.6±2.5，p = 0.006），注意到BMI的显着降低。我们还注意到CPAP组随访中的腹部左右的大效果尺寸。在随访评估时，CPAP组的平均心率（B / min）较低（58.6±9.5与67.8±7.8），同时初始（28.6％）和随访之间的心律失常增加（42.9％）评估不合规患者中的中间效应大小。结论：在我们的rhTN患者的rhTN患者中，对CPAP治疗的长期粘附与心律损失的减肥和改善有关。

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