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首页> 美国卫生研究院文献>Journal of the Endocrine Society >Alterations in Gut Microbiota Do Not Play a Causal Role in Diet-independent Weight Gain Caused by Ovariectomy
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Alterations in Gut Microbiota Do Not Play a Causal Role in Diet-independent Weight Gain Caused by Ovariectomy

机译：肠道微生物肿瘤的改变不会在卵巢切除术引起的饮食的体重增加中发挥因果作用

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Acute estrogen deficiency in women can occur due to many conditions including hyperprolactinemia, chemotherapy, GnRH agonist treatment, and removal of hormone replacement therapy. Ovariectomized (OVX) rodent models, often combined with a high-fat diet (HFD), have been used to investigate the effects of decreased estrogen production on metabolism. Since evidence suggests that gut microbes may facilitate the protective effect of estrogen on metabolic dysregulation in an OVX + HFD model, we investigated whether the gut microbiome plays a role in the diet-independent weight gain that occurs after OVX in adult female mice. 16S rRNA gene sequence analysis demonstrated that OVX was not associated with changes in overall gut bacterial biodiversity but was correlated with a shift in beta diversity. Using differential abundance analysis, we observed a difference in the relative abundance of a few bacterial taxa, such as Turicibacter, 3 to 5 weeks after OVX, which was subsequent to the weight gain that occurred 2 weeks postsurgery. A cohousing study was performed to determine whether exposure to a healthy gut microbiome was protective against the development of the metabolic phenotype associated with OVX. Unlike mouse models of obesity, HFD maternal-induced metabolic dysregulation, or polycystic ovary syndrome, cohousing OVX mice with healthy mice did not improve the metabolic phenotype of OVX mice. Altogether, these results indicate that changes in the gut microbiome are unlikely to play a causal role in diet-independent, OVX-induced weight gain (since they occurred after the weight gain) and cohousing with healthy mice did not have a protective effect.
机译：由于许多条件，妇女急性雌激素缺乏可能发生在包括高抗癌症，化疗，GNRH激动剂治疗和移除激素替代疗法的情况下发生。卵巢切除术（OVX）啮齿动物模型通常与高脂饮食（HFD）相结合，用于研究雌激素产生降低对代谢的影响。由于证据表明，肠微生物可以促进雌激素在OVX + HFD模型中对代谢失调的保护作用，我们研究了肠道微生物组是否在成年女性小鼠中ovx后发生的饮食的重量增益起作用。 16S RRNA基因序列分析证明，OVX与整体肠道细菌生物多样性的变化无关，但与β多样性的变化相关。使用差分丰度分析，我们观察到少数细菌征集的相对丰度，例如Turicibacter，ovX后3至5周，其在后期2周发生的体重增加之后。进行舒张研究以确定是否暴露于健康的肠道微生物组是对与OVX相关的代谢表型的发展受保护。与肥胖的鼠标模型不同，HFD母体诱导的代谢失调或多囊卵巢综合征，与健康小鼠的蜂巢小鼠保持舒张小鼠并未改善OVX小鼠的代谢表型。总的来说，这些结果表明，肠道微生物组的变化不太可能在饮食无关，OVX诱导的体重增加（自体重增加后发生以来）和健康小鼠的舒张没有保护作用。

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